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36 Cards in this Set

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Antipsychotics
Haloperidol, thioridazine, fluphenazine, chlorpromazine.

Block D2 rec
Neuroleptic malignant syndrome
Tardive Dyskinesia
Atypical Antipsychotics
Clozapine, Olanzapine, Risperdone

Block 5-HT2 and Dopamine rec
Tx pos and neg sx of schizoph.
Olanzapine for OCD
Clozapine - agranulocytosis
Bipolar
Lithium
Inhibition of phosphoinositol cascase -
SE - tremor, hypothyroid, polyuria, ADH antagonist, teratogen.
Phenytoin
incr Na channel inactivation
used for tonic clonic
Class 1B antiarhythmic
hirsuitism, megaloblastic anemia
SSRi
Fluoxetine, sertaline, citalopram, paroxetine
Use: endogenous depression, OCD
MAOi
contraindications
Phenelzine, tranylcypromine
Incr level of amines
Use - atypical depression, anxiety, hypochondria
contraindicated with SSRI, and beta agonists
Heterocyclic antidepressants
Treatment for major depression
Buproprion
Venlfaxine -inhibit NE, DA, Ser reup, generalized anxiety d/o
Mirtazipine alpha 2 antag (incr NE and Ser), potent 5HT2 and 5HT3 rec antag
Maprotiline - block NE reup
Trazadone - SE priapism
Anesthetic general principle
decr lipid solubility = faster induction and recovery = N2O
incr lipid solubility = incr potency = 1/MAC = Halothane high lipid solubility, slow induction high potentcy
Inhaled anesthetics
Halothane, Nitrous, enfluorane, isoflurane, sevoflurane, methoxyflurane
incr cerebral bloodflow, decr metabolic demand
SE -hepatotoxic (halothane), nephrotoxic (methoxyflurane), SZ (enflurane) - rare malignant hyperthermia
IV anesthetics
Barbs - thiopental - high potentcy, short surg procedures and induction of anesthesia
Benzo - midzolam - endoscopy
Arylcyclohexamines - ketamine
opiates
Propofol - rapid anesthesia induction and short procedures.
Local Anesthetics
mechanism
Esters - procaine, cocaine, tetracaine
Amides - lidocaine, bupivicaine, mepivicaine
Block Na channel
1. Infected tiss (acidic) requires more bc they are charged
2. Order of nerve block small diameter>large dia.
Myelinated> unmyelinated.
Size is more imp than myelination.
Order of loss pain>temp>touch>press
3. Given with EPI
Used for minor surgical, spinal anesthesia.
If allergic to esters give amides.
Severe cardiotoxicity with bupivicaine.
Succinylchoine
Depolarizing musc block
Reversal
Phase 1 - prolonged depol - no antidote - cholinesterase inhibitor potentiates effect
Phase 2 repolarized but blocked - antidote cholinesterase inhibitor (neostigmine)
Nondepolarizing neuromusc block
Tubocurarine, atracurium, mivacurium, pancurium, vecurium, rapacurium.
Compete with Ach for Rec
Reversal of block with cholinesterase inhibitors (neostigmine, edrophonium, etc)
Dantrolene
Prevents rls of Ca++ from SR of skeletal muscle cell.

Used for Tx of malignant hyperthermia from inhaled anesthetics (nitrous, halothane) and succinylcholine).

Also used for neuroleptic malignant syndrome (antipsychotic drugs)
Mirtazipine
heterocyclic antidepressant
major depression
alpha2 rec antag
potent 5HT2 and 5HT3 rec antag
Maprotiline
heterocylcic antidepressant
major depression
Ne reup inhibitor
citalopram
SSRI
Sertaline
SSRI
Trazadone
heterocyclic
inhibit Seratonin reuptake
Olanzapine
atypical antipsychotic
inhibits 5-HT2 and Dopamine rec
OCD, anxiety, depression, mania, tourettes.
Chlorpromazine
antipsychotic
blocks D2 rec
SE of antispychotics
Extrapyramidal Symptoms
4h - acute dystonia,
4d - akinesia
4wk - akathisia
4 mo - irrev Tardive Dyskinesia
Endocrine - dopa block se
Musc block - dry mouth, constipation
alpha - HoTN
his block- sedation
SE of block dopa rec
hyperprolactinemia -> gynecomastia
Amitryptiline and nortriptyline
TCA -
major depression
doxepin
TCA
Clomipramine
TCA
Major depression
OCD
Deprenyl
Selegiline
MAOBi
inhibits the degradation of DA
Parkinsons RX
Bromocriptine
Pergolide
Same class of Dopamine receptor agonists
Poliomyelitis
Vit B12 def
Friedrich Ataxia
Werdnig Hoffman
Polio and Werdnig Hoffman- LMN dz, destroyed Ant horn - flaccid paralysis
Vit B12 def and Friedrich Ataxia -demyelination of dorsal columns, LCST, Spinocerebellar tract, ataxic gait, hyperreflexia, impaired proprioception.
Friedrichs -ataxia in lower extremity that spreads to upper extremity followed by paralysis and contracture.
Complete occlusion of ventral art
only spares doral columns and tract of lissauer
complete paralysis
MS
mostly white matter of cervical region. random asymmetric lesions
Analogue of myelin basic protein for MS
Glatiramer Acetate
induces change in CMI
Baclofen
Muscle relaxant used in MS
Mitoxantrone
Suppresses CMI in secondary progression of MS
Natilizumab
antibody for specific adhesion molecules reducing leukocyte entry into CNS. Effective Tx for MS
Marcus Gunn pupil
Paradoxical Light reflex.
Nl light will make both eyes constrict
In a retinal detachment example because the affected pupil is not receiving enough light when shone with light in affected pupil both eyes will dilate to get as much light as possible.
atrophy of optic nerve will cause as well