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8 Cards in this Set
- Front
- Back
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Multiple Sclerosis (MS)
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Autoimmune, relapsing chronic disease, causes demyelination of the CNS, Brain, Optic nerve, etc. causes
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Main Genetic association with Multiple Sclerosis (MS)
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HLA-DR2
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CSF finding for people with MS
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oligoclonal bands of IgG, and oligoclonal CD-4 lymphocytes
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Acute lesion seen in patients with MS
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well circumscribed plaque, area of demyelination of white matter. periventriclular. looks like gray matter in white matter
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Pathology of the peri-ventricular plaques seen in MS
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destruction of the myelin sheaths of the axons, axons are not affected, so after resolution of flare up, symptoms will go away
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Clinical presentation of MS
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weakness or loss of sensation in extremities. optic neuritis, visual loss, internuclear opthamoplegia. hemi paresis
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Treatment of MS
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Treatment of flare ups is with high dose steroids
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Central Pontine myolenolysis
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malnurished patient with low Na. When Na is corrected too quickly, causes demyelination of basis pontus. causes death
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