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20 Cards in this Set
- Front
- Back
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Stept pneumoniae: Virulence Factors
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BACTERIAL MENINGITIES
Adhesions: PspA, CpbA: binds CHO on cell surface IgA protease Pneumolysin (Pla): cytotox. released when bacteria lyse Autolysin (LytA): release causes bacteria to release intracell. contents Peptidogly (PG) & teichoic acid (TA) = capsule, result in tissue damage |
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Strept pneumoniae: E/P
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BACTERIAL MENINGITIES
Person --> person, aerosol or direct |
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Strept pneumoniae: Clin ID
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BACTERIAL MENINGITIES
Gram pos Lancet shaped catalase neg alpha hemolytic optochin sens bile soluble Quellung RXN |
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Neisseria meningitidis: Virulence Factors
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BACTERIAL MENINGITIES
IgA protease Pili: pil proteins LOS: toxic & pro-inflamm Capsule: A, B, C, Y, W135 |
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Neisseria meningitidis: P/E
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BACTERIAL MENINGITIES
Person --> person nasal carriage normal Sympt: same as meningitis, accomp w/ rash/petechiae (can be fulminating) |
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Neisseria meningitidis: Clin ID
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BACTERIAL MENINGITIES
Gram neg diplococci fastidious: chocolate agar oxidase positive glucose/maltose fermentation |
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Hib: Virulence
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BACTERIAL MENINGITIES
IgA protease, LPS Capsule (A-F): B resp for most meningitis |
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Hib: P/E
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BACTERIAL MENINGITIES
person --> person, aerosol or direct |
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Hib: Clin ID
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BACTERIAL MENINGITIES
Gram neg pleomorphic coccobacilli facultative anaerobe fastidious growth: chocolate agar, factor V, Factor X |
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Mycobacterium tuberculosis: Vir Fact
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BACTERIAL MENINGITIES
2 step process: 1. Infect lung macrophages 2. diss to blood via lymphatics |
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Myocobacterium TB: E/P
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BACTERIAL MENINGITIES
inhalation of aerosol, person --> person Enters lungs first and disseminates to blood |
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Borrelia burgdorferi: VF
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BACTERIAL ENCEPHALITIS
Lyme disease Dissemination: inflammatory response & lesion at site of bit spread through blood Localize in tissue after months (CNS, skin, joints) |
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Borrelia burgdorferi: P/E
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BACTERIAL ENCEPHALITIS
tick bite symp: initial skin lesion, arthritis, neurological problems |
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Borrelia burgdorferi: Clin ID
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BACTERIAL ENCEPHALITIS
Spirochete Microaerophilic Rqs BSK-II to culture Use serologic test |
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Treponema pallidum: VF
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BACTERIAL ENCEPHALITIS
Tert syph. |
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Treponema pallidum: P/E
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BACTERIAL ENCEPHALITIS
STD 3 stages Genital chancre |
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Treponema pallidum: Clin ID
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BACTERIAL ENCEPHALITIS
Gram neg Spirochete |
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Campylobacter jejuni: VF
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POST-INFECTIOUS:
GUILLAIN-BARR only 800 org needed chemotaxis, motility, flagella: attach to gut epithelium |
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Campylobacter jejuni: E/P
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POST-INFECTIOUS:
GUILLAIN-BARR contaminated food acute paralysis G-B: demyelinating disorder: immunologic attach on peripheral myelin (X-Rxn: microbial gangliosides and neural Ag) |
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Campylobacter jejuni: Clin ID
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POST-INFECTIOUS:
GUILLAIN-BARR Gram neg curved rods microaerophilic motile |
