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15 Cards in this Set
- Front
- Back
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Empiric Therapy: S. pneumoniae & N. meningitides |
Dexamethasone - glucocorticoid Cefotaxime - inhibit cell wall synthesis Vancomycin - inhibit cell wall synthesis |
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S. pneumonia |
Pen G MIC <0.1: Pen G or Ampicillin + Dexamethasone Pen G MIC >0.1: Ceftriaxone + Vancomycin +Dexamethasone |
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N. meningitides |
Ceftriaxone - inhibit cell wall synthesis |
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Listeria monocytogenes |
Ampicillin - inhibit cell wall synthesis Gentamicin - aminoglycoside; inhibit protein synthesis |
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Strep agalactinae (GBS) |
Ampicillin - inhibit cell wall synthesis Cefotaxime - inhibit cell wall synthesis |
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Cryptococus neoformans |
Amphotericin B - binds ergosterol, increase membrane permeability Flucytosine - disrupt protein synthesis Fluconazole - inhibits lanosterol to ergosterol |
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HSV-1 |
Acyclovir - Activated by viral thymidine kinase Host kinase converts to active form Inhibits DNA polymerase |
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Taenia solium |
Albendazole - binds tubulin & inhibits microtubule synthesis Dexamethasone - glucocorticoid |
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Toxoplasma gondii |
Pyrimethamine - blocks dihydrofolate reductase Sulfadiazine - inhibits dihydrofolate synthesis Leucovorin - rescue agent to prevent adverse hematologic effects of pyrimethamine |
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Adverse effect: Vancomycin |
nephrotoxic, ototoxic, rash |
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Adverse effect: Ampicillin |
hypersensitivity |
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Adverse effect: Gentamicin |
nephrotoxic, ototoxic |
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Adverse effect: Amphotericin B |
nephrotoxic |
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Adverse effect: Fluconazole |
many drug interactions (P450)` |
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Adverse effect: Ayclovir |
phlebitis, renal dysfunction (reverseable) |
