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9 Cards in this Set
- Front
- Back
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Drug Classes for Psychoses
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Phenothiazines: Most effective for hallucinations & delusions
Nonphenothiazines: less sedation & reduced anticholinergic effect, AE similar to Phenothiazines |
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Phenothiazines and Nonphenothiazines Drug Therapy
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Phenothiazines:
MOA: Blocks post synaptic dopamine receptors AE: Sedation, Drowsiness, Sexual dysfunction, Hypotension, Parkinson-like symptoms, Spasms of back muscles, tongue & face, Dry mouth, Tachycardia, Tardive dyskinesia Contraindications: Alcohol withdrawl, Coma, Brain damage, Bone marrow depression, Reye syndrome, Lactation Nonphenothiazines: Contraindications: Parkinson disease, seizure disorders, alcohol abuse, severe depression Route: Oral, IM, IV |
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Phenothiazines (Drugs)
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chlorpromazine hydrochloride/Thorazine
*used for more than 50 years fluphenazine hydrochloride/Permitil,Prolixin perphenazine prochlorperazine/Compazine thioridazine hydrochloride trifluoperazine hydrochloride |
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Nonphenothiazines (Drugs)
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haloperidol/Haldol
loxapine succinate molindone hydrochloride/Moban pimozide/Orap thiothixenehydrochloride/ Navane |
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Extrapyramidal Side Symptoms (EPS)
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*SAE from antipsychotic meds
Symptoms: Acute dystonia (muscular spasms), Akathisia (inability to rest or relax), Parkinsonism, Tardive dyskinesia |
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*Drugs to treat EPS*
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*benztropine mesylate/Cogentin to treat acute dystonia*
beta-adrenergic blockers & benzodiazepines for akathisia |
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Atypical Antipsychoses for Psychoses (Drug Therapy)
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*DRUGS OF CHOICE
MOA: largely unknown, thought to block D2 Receptors, Serotonin, & alpha-adrenergic receptors AE: Weight gain, Diabetes, Hypertriglyceridemia, increase risk of cerebrovascular events Contraindications: Underlying cardiovascular disease, Seizure disorder, suicidal ideas, kidney/liver disease -Treat both positive & negative symptoms associated w/ schizophrenia -have fewer AE than Phenothiazines and Nonphenothiazines |
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Atypical Antipsychotics (Drugs)
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apripiprazole/Abilify
olanzapine/Zyprexa quetiapine fumarate/Seroquel risperidone/Risperdal ziprasidone hydrochloride/Geodon clozapine/Clozaril paliperidone/Invega Route: Oral, IM |
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Dopamine System Stabilizers
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*Newest med for Psychoses
*ONLY DRUG IN CLASS: oripiprazole/Ambilify MOA: Blocks dopamine & serotonin receptors AE: HA, Insomnia, Dizziness, Tremor, Tardive dyskinesia, Blurred vision, Akathisia, Orthostatic Hypotension, Nausea/Vomiting, Diarrhea, Rash, Cough, Increase suicide risk, Esophageal motility Contraindications: Lactation, Pregnancy, Cerebral vascular disease, Seizure disorders, Alzheimer dementia, Dysphagia, Parkinsonism Route: Oral & IM |
