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11 Cards in this Set
- Front
- Back
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Altered GABA causes:
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Seizures,
Bipolar Disorders, Anxiety, Insomnia |
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Altered dopamine causes:
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Parkinson's disease,
Schizophrenia |
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Altered serotonin (5-HT) causes:
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Schizophrenia,
Depression |
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Molecules that can cross BBB:
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very small & lipophilic
Gases - O2, CO2 Some drugs (ex. Diazepam) |
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Specific transport systems allow polar (water soluble) or large molecules to cross BBB s/a:
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glucose,
amino acids, some drugs (ex. Phenobarbital) ***drugs that are highly ionized or protein bound CANNOT cross |
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_____ is primary excitatory NT in the CNS
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Glutamate
(SPEEDS UP SYSTEM) |
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Glutamate ionotropic-ligand gated ion channels are:
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- direct: Na+, Ca++, indirect: Ca++ (K+ closed)
- influx of (+) ions depolarizes membrane |
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GABA ionotropic-ligand gated ion channels are:
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- directL Cl-, indirect: K+ (Ca++ closed)
- influx of (-) ions hyperpolarize membrane |
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Glutamate receptors:
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Metabatropic- GPCRs
- mGluR - Post-synaptic: involved in transmission of signal, Gq coupled → releases more Ca++ (increase AP) - Pre-synaptic: regulate further release of NT, Gi coupled → negative feedback (stop release of Ca++) |
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_____ is primary inhibitor NT in the CNS.
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GABA
(Budah - sloowwwss down system) |
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GABA receptors:
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GABAaR activation:
Presynaptic neuron depolarization: Ca++ influx & GABA release to postsynaptic → Cl- enters, K+ leaves = hyperpolarized (harder to have AP) |
