Cns Affected Disorders Pjm Lecture 1

Front 1

Affected Disorders?

Back 1

A group of disorders characterised by clinically signnificant mood disturbannces

Front 2

3 major categories of affected disorders?

Back 2

1) Major - depressive illnness
2)Minor - Cyclothymic or Dysthymic disorder
3)Bipolar depressionn (mania) - depressive episodes flutuate with episodes of mania

Front 3

Unipolar Depression?

Back 3

Reactive - 75% of cases, non-familiar, assciated with stressful life, axienty and agitation
Endrigenous, 25% of cases, familiar, unnrelated to external stressors

Front 4

Emotional presenting symptoms of depressive illness?

Back 4

Misery, apathy, pessimism
Low self-esteem, feelings of guilt and inadequacy
Indivciveness, loss of motivationn

Front 5

Biological symptoms of depressive illness?

Back 5

Retardation of thought annd actionn
Loss of libido
Sleep disturbances
Loss of apptite

Front 6

Core symptoms of Depression? (8)

Back 6

1)Depressed mood
2)Loss of intrest or pleasuer (anhedonia)
3)Appetite or sleep disturbances
4)Agitation or retardation
5)Loss of energy
6)Self-blame
7)Impaired concentration
8)Suicidal thoughts

Front 7

Requirements for diagnosis of depression? (3)

Back 7

1)In addition to depressed mood or loss of intrest 4 or more of the core symptoms indicate a definite diagnosis of depression
2)A total of 4 core symptoms is probably enough for the diagnosis
3) Two weeks or more duration of illnenss

Front 8

Rating Scales? (3)

Back 8

1) HAM-D - 21 symptoms with diffrent max scores
2)MADRS - 10 symptoms, scored 0-6
3) Self rating scales - Beck depression inventory, Zung self-assesment depression scale

Front 9

Treatment of depressive illnenss?

Back 9

ECT
Drugs - MAOIs, TCAs, SSRIs, SNRIs,
Cognitive behaviour therapy (CBT)

Front 10

ECT?

Back 10

Patients lightly aneasthetised
Paralysed with NMJ
Ventilated
Electrodes on either side of head
SE - confucsion and memory loss