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25 Cards in this Set
- Front
- Back
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What is another name for a macrophage?
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Histiocyte
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Cell migration along surface gradients
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Haptotaxis
*action of chemokines in chronic inf. |
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Suppress the release of TNF-alpha from phagocytes (2)
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1) Pentoxifylline
2) Talidomide |
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Antagonist to IL-1, TNF and INF-y
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TGF Beta
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Fusions of macrophages found on the outside of a granuloma
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Giant cell
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Type of giant cell found in TB
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Langhan's giant cell
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Type of cell with high rate of loss and replacement
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Labile cell
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Cell that does not normally proliferate to a great extent, but can after damage
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Stable cell
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Cell with an inability to divide after development and differentiation
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Permanent cell
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Loose connective tissue framework formed by capillary formation and fibroblast migration
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Granulation tissue
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Accumulation of excess collagen
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Keloid (hypertrophic scar)
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Excessive granulation tissue
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Proud flesh (exuberant granulation)
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Exuberant proliferation of fibroblasts
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Desmoids (aggressive fibromatoses)
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Macrophage in the liver
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Von Kupffer cell
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Dendritic cell within the skin
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Langerhans cell
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Granulomatous disease occurring in the lungs and lymph nodes with an unknown etiology
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Sarcoidosis
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Antogonist to IL-1, TNF, and INF-y
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TGF Beta
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Phagocytosis by macrophages of dead cell and debris, with the original tissue architecture intact
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Resolution
*occurs when there is little tissue destruction (ex: lobar pneumonia) |
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Proliferation of cells replaces lost tissue with reconstruction of the normal architecture
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Regeneration
*depends on: cell types, tissue architecture, amount of tissue lost |
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Fibrous scar produced from granulation tissue replaces lost tissue
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Repair
*1)Macrophage phagocytosis 2)Proliferation of endothelia and fibroblasts 3)Endothelial cells into damaged area |
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Growth factor that promotes collagen synthesis and inhibits collagenase secretion
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Transforming growth factor-B
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Growth factor that promotes collagen synthesis but also promotes collagenase secretion
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Platelet-derived growth factor (PDGF)
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Growth factor which is deposited into the ECM
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Fibroblast growth factor (FGF)
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Destabilize the cell-matrix interactions to promote angiogenesis
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Matricellular proteins
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Important in tissue remodeling during endothelial cell invasion
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Proteases (plasminogen activators and matrix metalloproteases)
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