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14 Cards in this Set
- Front
- Back
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No stars = Mentioned / In Slides
* = Important ** = Red in KFD's lectures *** = Mentioned to be on exam |
No stars = Mentioned / In Slides
* = Important ** = Red in KFD's lectures *** = Mentioned to be on exam |
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What is this called?
Naive T cells encounter it's specific antigen and is stimulated to differentiate into an effector T cell |
Priming (first step in any adaptive immune response) |
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**Where does activation of helper T cells occur for:?
Antigens in the skin and other peripheral tissues |
Regional Lymph Nodes |
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**Where does activation of helper T cells occur for:?
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Spleen |
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**Where does activation of helper T cells occur for:?
Antigens in the respiratory mucosa |
Tonsils and Bronchial-associated lymphoid tissue |
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**Where does activation of helper T cells occur for:?
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Peyer's Patches GALT (Gut-associated lymphoid tissue) Appendix |
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*How does antigen gets to secondary lymphoid tissue.... via what 2 cells rather? |
Dendritic Cells Macrophages |
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**How antigen gets to secondary lymphoid tissue:
Name the cell(s)
-Act as sentinels for infection in tissue -Upon infection, cell uptakes pathogens -Can process and present antigen |
Dendritic Cells and Macrophages |
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**How antigen gets to secondary lymphoid tissue:
Name the cell(s)
-Range of function in defense and repair of damaged tissue |
Macrophages |
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**How antigen gets to secondary lymphoid tissue:
Name the cell(s)
-Only known function is to *trigger T cell reponses* |
Dendritic Cells |
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**How antigen gets to secondary lymphoid tissue:
Activation of Dendritic cells induces expression of _______, the receptor for Chemokine __________ |
Activation of Dendritic cells induces expression of CCR7 (the receptor for Chemokine CCL21) |
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**How antigen gets to secondary lymphoid tissue:
Name the cell
-Can carry antigen load from site of infection to secondary lymphoid tissue |
Dendritic Cells |
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**How antigen gets to secondary lymphoid tissue:
Name the cell
-Resident in tissues, do not migrate -However, when these cells are resident in lymphoid tissue they can process and present antigen that is carried passively in lymph from infected tissue |
Macrophages |
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Immune Response:
-_____ T cells brought to lymph nodes via blood -Bind to __________ cells in thin walled ______ _______ ________ -Squeeze through vessel wall -Enter _______ region of lymph node -Pass through tissue, examine APC APC sees antigen: _______, _______, _______ APC doesn't see antigen: recirculate |
Immune Response:
- (NAIVE) T cells brought to lymph nodes via blood -Bind to (ENDOTHELIAL) cells in thin walled (HIGH) (ENDOTHELIAL) (VENULES) -Squeeze through vessel wall -Enter (CORTICAL) region of lymph node -Pass through tissue, examine APC ---APC sees antigen: (ACTIVATE), (PROLIFERATE), (DIFFERENTIATE) ---APC doesn't see antigen: recirculate |
