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29 Cards in this Set
- Front
- Back
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Can move through Epithelium
Can Polymerize to Dimer
Tears, Saliva, Vagina, Mucus |
IgA |
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Can polymerize to Pentamer |
IgM |
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Only 2 non-monomers |
IgA
IgM |
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Immunologic Memmory |
IgG |
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What 2 provide neutralization? |
IgG
IgA |
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Which one provides Opsonization |
IgG |
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Which one is sensitive to Mast cells |
IgE |
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Which 2 are involved in activation of complement |
IgM and IgG |
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First Antibody to be secreted * |
IgM |
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Activates complement via classical cascade |
IgM |
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How does a humoral immune response proceed via class switching? |
B cells undergo somatic hypermutation:
"mutation that occurs at high frequency in the rearranged variable region DNA of immunoglobulin genes in activated B cells, resulting in the production of variant antibodies, some of which have a higher affinity for the antigen"
IgM declines
IgG and IgA produced |
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What are the 4 functions of IgG? |
Precipitation
Agglutination
Complement Fixation
Neutralization |
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Describe Agglutination |
Clumping in petri dish due to positive result/antibody present.
IgG |
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Found in breast milk |
IgA |
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Protects mucosal surfaces |
IgA |
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Describe IgA secretory function |
Secreted on luminal side with a remnant of the poly-Ig receptor called secretory component*
Secretory component binds mucins, which keeps IgA bound microbes from attaching to epithelia |
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Provides a mechanism for the rapid ejection of pathogens from the body |
IgE |
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Parasites |
IgE |
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Little circulates in Plasma |
IgE |
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Sneezing, vomiting, diarrhea |
IgE |
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Allergies and Asthma |
IgE |
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Which Ig has trouble crossing endothelium because of its large size?
Which 2 can move through tissues? |
IgM
IgA and IgG can move through because are monomers |
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Crosses placenta |
IgG |
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What quantitative test for Antibodies gives quantitative results? |
ELISA |
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What kind of titer is taken while illness present |
Acute Titer |
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What kind of titer is taken after symptoms subside? |
Convalescent Titer |
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Means primary response |
IgM---- first to arrive |
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Means immune response |
IgG |
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This test tells which antigens in the prep are on the entity the patient is making antibodies for |
Western Blot Analysis |
