Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
33 Cards in this Set
- Front
- Back
|
SLE usually begins when?
|
ages 15-40
|
|
|
SLE affects what sex most often?
|
women
|
|
|
SLE possibly could possibly be influenced by what hormone?
|
estrogen
|
|
|
What are some possible drugs that can cause drug induced lupus?
|
-Procainamide
-hydralazine -Isoniazid -diphnylhydantoin -penicillamine |
|
|
What are the most common symptoms of drug induced lupus?
|
-fever
-sclerositis -arthritis |
|
|
What HLA's are increased in SLE?
other blood work that is increased? |
-HLA-B8
-HLA-DR2 -HLA-DR3 -ANA -increased Ig levels |
|
|
What are some skin findings in SLE?
|
-faint malar rash
-discoid lesions -photosensitive skin eruptions -uticaria -macular or papular eruptions -bulae -panniculitis -Raynauds -nail-bed telangiectasia -splinter hemorrhages -osler's nodes |
|
|
What are some serositis complications of SLE?
|
-pericarditis
-pleuritis -peritoneal infection |
|
|
What are some cardiac complications of SLE?
|
-vasculitis and coranary atherosclerosis
-valvulitis (esp of aortic and mitral valve) -aseptic endocarditis -pleuritis |
|
|
What are the most common neurological manifestations of SLE?
|
-seizures
-CVAs -lupus cerebritis |
|
|
What are some markers of renal disease found in SLE?
|
-hematuria
-proteinuria -some form of glomerulonephritis -the more diffuse the involvement the worse the prognosis |
|
|
What are some hematologic findings associated with SLE?
|
-anemia of chronic disease
-granulocytopenia -lymphopenia -mild thrombocytopenia -severe autoimmune thrombocytopenia |
|
|
4 or more of the following symptoms help to give a dx of SLE. What are those symptoms?
|
-malar butterfly rash
-discoid skin lesions -oral ulcers -photosensitivity -nonerosive arthritis -serositis -renal disorder -neurological disroder -hematologic disorders -immunologic disorders -ANA |
|
|
What is virtually diagnostic of SLE?
|
anti smill presence of high titers of antivative DNA autoantibodies
|
|
|
A negative ANA does what?
|
virtually exluces SLE, except for subacute cutaneous lupus
|
|
|
Subacute cutaneous lupus will have a positive what?
|
anti-Ro antibody
|
|
|
SLE often shows depression of what serum hemolytic component?
|
C2 most often
|
|
|
NSAIDS in SLE are used to tx what?
|
-arthritis
-serositis |
|
|
Anti malarial agents in SLE are used to rx what/
|
-arthritis
-dermatologic manifestations -ophthalmologic monitoring |
|
|
What are some indications for high dose corticosteroid therapy?
|
-severe multisystem disease
-serositis unresponsive to NSAIDS -cenral or peripheral nervous system disease -vasculiti -hemolytic anemia -immune thrombocytopenia -glomerulonephritis |
|
|
What are some SLE drugs that can be used that are also stroid sparing?
|
-Azathioprine
-Mycophenolate Mofetil -Methotrexate |
|
|
Cytotoxic drugs are primarily used for what?
|
active renal disease
|
|
|
What is the MCC of death in SLE?
|
infection
|
|
|
Involvement of what organ systems have the worst prognosis in SLE?
|
renal and CNS involvement
|
|
|
What are some serological features of SLE?
|
-ANA
-anti-DNA -anti-SM -anti-Ro -anti-La -anti-histone in drug induced lupus |
|
|
SLE is linked to what?
|
increased lymphocyte activity (IL-1)
|
|
|
A minority of pts only have what?
|
-skin lupus
|
|
|
What are some clinical features of SLE? There are a lot
|
-fatigue, wt loss, fever
-facial butterfly rash, alopecia, photosensitivity, vitiligo -personality disorders, seizures, psychosis, mononeuritis multiplex -pericardial effusions, mycarditis -pleuritis, pleural effusions, pneumonitis -abdominal complaints -any type of GN -MSK damage |
|
|
What lab finding in SLE is highly suggestive of the dz?
|
hypocomplementemia (C3 and C4)
|
|
|
Just know that:
|
anti-dsDNA and anti-SM are found in SLE
|
|
|
Antiphospholipid antibodies in SLE
1-increased risk of what? 2-PTT may be high,but…. 3-may have a false test for what? 4-is associated with what other ab? |
1-miscarriage risk
2-PTT may be high, but it is false and means thrombosis 3-false test for syphilis (DVRL) 4-anticardiolipin ab is also present |
|
|
What is the tx for SLE?
|
-heparin for thrombosis
-NSAIDS for serositis, fever, joint pain -steroids for skin symptoms -hydroxychoroquine for rash, phosensitivity vitiligo |
|
|
What are some s/e of anti-malarials?
|
neuropathy and impaired night vision
|
