Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
35 Cards in this Set
- Front
- Back
|
Is Hodgkin's Lymphoma a common disease?
|
no
|
|
|
What are the peak ages for Hodgkins?
|
bimodal
-15-35 -50+ |
|
|
Hodgkins affects males or females more?
|
males
|
|
|
Hodgkins is increased incidence in what pts?
|
immunodeficiency and autoimmune disease
|
|
|
Hodgkins is first seen with what clinical feature?
|
mass or group of lymph nodes that are firm, nonfixed, and nontender
|
|
|
In Hodgkins, adenopathy is common where?
|
neck/supraclavicular area
|
|
|
50-60% of Hodgkins pts ahve lymphadenopathy where?
|
mediastinal
|
|
|
40% of Hodgkins pts have low grade feve with what?
|
recurrent night sweats, which is more common in advanced disease and older ppl
|
|
|
What abdominal finding is common in Hodgkins pts?
|
hepatosplenomegaly
|
|
|
What lymph nodes should get a biopsy?
|
those > 1cm for more than 4-6 weeks
|
|
|
What types of cells confirm the dx of Hodgkins?
|
Reed-Sternberg cells
|
|
|
What type of anemia is present in Hodgkins?
|
normochromic-normocytic anemia (ACD)
-elevated Fe stores -low TIBC |
|
|
What type of reaction is seen in Hodgkins?
|
marked leukemoid reaction
|
|
|
What is the tx for Hodgkins?
|
radiotherapy for early stage and chemo
|
|
|
What is Waldenstom’s Macroglobulinemia?
|
-low grade malignant lymphoma that secrete excessive amounts of IgM
-bone marrow, lymph nodes, spleen, and liver infiltration is common |
|
|
What are some clinical manifestations of Waldenstom’s Macroglobulinemia?
|
-symptoms of anemia or macroglobulin
-Raynauds -hyperviscosity -protein-protein interaction |
|
|
How is the dx of Waldenstom’s Macroglobulinemia made?
|
¬-by presence of nonoclonal IgM on serum plasma electrophoresis and infiltrates in bone marrow or lymph nodes
|
|
|
HL is a malignancy of what?
|
-lymphoid system
HL tumors are composed of what and characterized by what cells? -composed of non-malignant cells that are apparently non-reactive and characterized by Reed-Sternberg cells |
|
|
Reed-Sternberg cells have a what cell type origin?
|
B cell origin
|
|
|
What are the 4 main types of HL?
|
-lymphocyte predominant
-nodular sclerosis (likes mediastinum) -mixed cellularity (HIV pts) -lymphocyte depletion subtypes (widespread at time of dx) |
|
|
HL usually presents with a painless mass where?
|
neck, axial or groin, but mostly neck
|
|
|
The mass is HL is what?
|
-rubbery
|
|
|
What are the paraneoplastic systemic B symptoms of HL?
|
-unexplained fever, weight loss, and night sweats
-less favorable prognosis |
|
|
How does HL mainly spread?
|
contiguous extension to adjacent nodal groups and structures
|
|
|
What do labs show in HL?
|
-anemia of chronic disease
-nephrotic syndrome |
|
|
NON-HL is malignant neoplasms of where?
|
-immune systems
|
|
|
In non-HL there is proliferation of what?
|
-malignant B or T lymphocytes
|
|
|
Cells in non-HL are what?
|
monomorphic and monoclonal
|
|
|
How does non-HL spread?
|
hematogenuously to diverse sites
|
|
|
High grade lymphomas in non-HL are seen in what pts?
|
-younger pts
|
|
|
What is associated with non-HL?
|
-immunosuppresion
|
|
|
What are some possible causes of non-HL?
|
-EBV
-prior tx for HL -HTLV-1 is implicated |
|
|
What are some clinical manifestations of non-HL?
|
-unidentified organ disease process
-hepatosplenomegaly and widespread palpable adenopathy are more common -abdominal mass -may involve CNS and bone marrow |
|
|
How is the dx of non-HL made?
|
-lymph node bx
-bone marrow bx |
|
|
What is the hallmark finding for non-HL?
|
-clonal lymphocyte populations
-bone marrow bx is required |
