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22 Cards in this Set
- Front
- Back
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thrombin
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final protease to be generated, cleaves fibrinogen to fibrin
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thrombin-extrinsic
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tissue factor exposed
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thrombin-intrinsic
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on the surface of platelets or other cells
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decrease in pgi2
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cause platelets to become reactive-recruit platelets and adhere to matrix
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white thrombus (arterial)
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forms in rapid arterial circulation and is made of platelets and fibrin
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red thrombus (venous)
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forms in injured vein and is made of fibrin, RBC's, and fewer platelets
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platelets adhere to
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vWF and collagen when pgi2 is low
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thrombin is and does...
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serine protease, increases intracellular calcium and platelet shape change
**releases adp and txa2 |
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thrombin receptor
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PAR1, proteolytic process
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heparin
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polysaccharide, stimulates natural inhibitors of coagulant proteases
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heparin MOA
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binds to antithrombin III and makes conformational change (inhibits thrombin)
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reverse heparin
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protamine sulfate
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warfarin
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similar to vitamin k, forms abnormal clotting factors that do not work
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drug interactions-warfarin
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phenylbutazone, phenytoin, barbiturates, aspirin
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reverse warfarin
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give vitamin k1 (phytonadione)
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aspirin
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blocks conversion of arachidonic acid to thromboxane A2
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ticlopidine and clopidogrel
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inhibits ADP induced platelet aggregation
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abciximab
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mouse monoclonal antibody, directed against GP IIb-IIIa receptor
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eptifibatide
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peptide derived from rattlesnake venom, directed against GP IIb-IIIa receptor
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streptokinase
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dissolves clots by binding to plasminogen and converts to plasmin
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urokinase
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dissolves clots by binding to plasminogen and converts to plasmin
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tissue plasminogen activator (tpa)
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converts plasminogen to plasmin, which lyses fibrin clots
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