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22 Cards in this Set

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thrombin
final protease to be generated, cleaves fibrinogen to fibrin
thrombin-extrinsic
tissue factor exposed
thrombin-intrinsic
on the surface of platelets or other cells
decrease in pgi2
cause platelets to become reactive-recruit platelets and adhere to matrix
white thrombus (arterial)
forms in rapid arterial circulation and is made of platelets and fibrin
red thrombus (venous)
forms in injured vein and is made of fibrin, RBC's, and fewer platelets
platelets adhere to
vWF and collagen when pgi2 is low
thrombin is and does...
serine protease, increases intracellular calcium and platelet shape change
**releases adp and txa2
thrombin receptor
PAR1, proteolytic process
heparin
polysaccharide, stimulates natural inhibitors of coagulant proteases
heparin MOA
binds to antithrombin III and makes conformational change (inhibits thrombin)
reverse heparin
protamine sulfate
warfarin
similar to vitamin k, forms abnormal clotting factors that do not work
drug interactions-warfarin
phenylbutazone, phenytoin, barbiturates, aspirin
reverse warfarin
give vitamin k1 (phytonadione)
aspirin
blocks conversion of arachidonic acid to thromboxane A2
ticlopidine and clopidogrel
inhibits ADP induced platelet aggregation
abciximab
mouse monoclonal antibody, directed against GP IIb-IIIa receptor
eptifibatide
peptide derived from rattlesnake venom, directed against GP IIb-IIIa receptor
streptokinase
dissolves clots by binding to plasminogen and converts to plasmin
urokinase
dissolves clots by binding to plasminogen and converts to plasmin
tissue plasminogen activator (tpa)
converts plasminogen to plasmin, which lyses fibrin clots