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7 Cards in this Set
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picturing gene therapy |
direct delivery- therapeutic transgene, the therapeutic transgene is packaged into a delivery vehicle such as a virus->and injected into the patient->target organ. Cell-based deliverytherapeutic transgene->the thereupeutic transgene is packaged into a delivery vehicle such as a virus->the therpeut transgene is introduced into a delivery cell sch as a stem cell that is often derived from the patient-> the geneticaly modified cells (eg stem cells) are multiplied in the lab->and eadministered to th patoent->target organ (eg, liver) |
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cell based delivery |
not direct delivery->some viruses commonly used are only good when cells dividing neural cells other than NSCs don't divide much |
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therapeutic cloning |
therapeutic cloning, also called embryo cloning, is the production of human embryos for use in research the goal is to harvest stem cells tht can be used to study human development and to treat disease stem cells can be used to generate virtualy any type of specialized cell in the human body stem cells are extracted from the egg after is had divided for 5 days (called a blastocyst) the extraction process destroys the embryo, which raises a variety of ethical concerns
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stupid picture about stem cells |
person who needs new organ or tissue-> adult cell from patient. ALSO human ovum--> mild electirc shock+remove nucleus , empty ovum. -> new pre-embryo cell containing patient DNA->embryonic development begins-?stemcells removed from embryo and cultured to grow into require organ or tissue->organs and tissues->->organ or tissue transplanted into patient with no rejection problems! |
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the generation of induced pluripotent stem cells |
1. isolate and culture host cells 2. introduce the ES specific genes (iPS factors_ into the cells by using retrovirus vector. Red cells indicate the cells expressing the exogenous genes 3. harvest and culture cells according to the method for ES cell culture using feeder cells 4. a subset of the cells generates ES-like colonies, that is, iPS cells |
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dolly the sheep |
dolly is famous because she wsa the first animal cloned from an adult somatic nucleus |
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reproductive cloning |
reslts in producion of genetially identitcal individual involves the productino of offspring from an adult (differentiated) somatic cell in a process called somatic cell nuclear transfer is an inefficient process high percentage of deformity |
