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7 Cards in this Set
- Front
- Back
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Clonidine - Pharmacokinetics - Absorption |
Absorption - oral bioavailability - almost 100% |
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Distribution |
Very lipid sol penetrates CNS 20% PPB VD 2lt/kg |
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Metabolism |
35% liver to INACTIVE metabolites 65% unchanged in urine 20% excreted in faeces 2-4ml/kg/min T1/2 Beta - 6-23hrs Markedly increased in renal failure |
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PD - CNS |
CNS Presynpatic in SC Postsynaptic at brainstem/PAG Analgesic, sedatory, MAC sparing, anxiolytic - can cause dysphoria/paradoxical agitation |
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PD - Resp |
Resp stable, nil depression |
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PD - CVS |
Bradycardia, hypotension via decreased SNS Can cause initial hypertension via direct Alpha 2 effects |
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PD - Other |
GI - nauseant, antisialologue, decreased motility Urinary - nil change in gfr uterine - no effects Allergy - nil ADRS - bradycardia, rebound hypertension, dry mouth, cns disturbance, impotence, constipation. |
