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50 Cards in this Set
- Front
- Back
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name of the requirements that most biomedical journals require authors to comply with
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Uniform requirements for manuscripts submitted to biomedical journals
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who prepared the uniform requirements for manuscripts submitted to biomedical journals
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International Committee of Medical Journal Editors (ICMJE)
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ICMJE stands for
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International Committee of Medical Journal Editors
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Uniform requirements include
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ethical considerations
IMRD |
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there are uniform requirements that all research must comply with. In addition there are guidelines (list 5)
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CONSORT statement
PRISMA STROBE MOOSE STARD |
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which guidelines are for RCTs
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CONSORT statment
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which guidelines are for systematic reviews
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PRISMA
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which guidelines are for observational studies in epidemiology
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STROBE
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which guidelines are for meta-analyses of obervational studies
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MOOSE
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which guidelines are for reporting diagnostic accuracy studies
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STARD
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length of manuscript
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3000 words
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length of title
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<15 words
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length of abstract
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250-500 words
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length of intro
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600 words
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length of methods
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3-4pgs
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length of results
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2-3 pgs
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tables and figures
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<6 pgs
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discussion length
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3-5 pages
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# of references
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30-40
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3 styles of title
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descriptive
interrogative affirmative |
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what is in an introduction (6)
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why of the study
what is known what is unknown importance objectives/hypotheses hypothesis should be justified by literature |
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which part did she say was most important (of the IMRD)
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methods
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CONSORT stands for
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consolidated standards of reporting trials
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review slide 27 and 28
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ok
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the degree to which conclusions are correct for the sample in the study
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internal validity
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questions to ask when determining if a study has internal validity (2)
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1. what factors may affect the dependent variable?
2. what is the likelihood of the comparison groups differing on each of these factors 3. is there systemic error? (bias) |
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unequal provision of care = _____ bias
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performance
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biased allocation to groups = _____ bias
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selection
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biased allocation to groups = ____ bias
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selection
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biased outcome assessment = _____ bias
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detection
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biased occurrence and handling of protocol deviations and loss to follow up = _____ bias
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attrition
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degree to which study results can be applied to people outside the study
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external validity
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questions to ask when assessing external validity
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1. who was included?
2. how does the trial compare with clinical practice? |
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internal validity vs. precision
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internal validity = free of bias
precision = free of random error (in either direction) |
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systemically developed statements which assist clinicians and patients in making decisions about appropriate treatment for each specific condition
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clinical practice guidelines
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other role of clinical practice guidelines (other than direct patient care
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health policy formation
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what is required for an author to take on public responsibility for the work (AKA be a named author)
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"sufficient" contribution
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abstract AKA
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abridged scientific report
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is structured or unstructured abstract better
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structured - you can find stuff more easily
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structured vs. unstructured abstract
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structured has headings
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things that should be considered when reading a methods section
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- how were the subjects selected?
- are outcome measures are sample size estimation justified |
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CONSORT checklist
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identify as randomized trial in the title
sources of funding and role of funders |
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studies have examined the effect of poor design on results - 3 things that yield higher estimates of treatment effects
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inadequate sequence generation
inadequate allocation concealment lack of double blinding |
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one methodological problem for which it is unclear whether trials have higher estimates of treatment effects
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attrition of patients
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degree to which the conclusions are correct for the sample in the study
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internal validity
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extent to which systematic error (bias) is minimized
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internal validity
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bias is related to internal or external validity
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internal
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unequal provision of care (type of bias)
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performance
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internal validity vs. precision
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internal validity is related to systematic error (bias and confounding)
bias distorts the truth directionally precision is related to random (chance) error chance could bias estimates in either direction |
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questions to ask when evaluating precision
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what are the treatment effects
are they precise are they important |
