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20 Cards in this Set
- Front
- Back
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What will decreased ATP lead to in the heart?
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because ATP is needed to get rid of calcium, the heart will not be able to relax and will becomes stiff
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what pressure will increase in an ischemic heart?
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increased end-diastolic filling pressure
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what is the last thing to occur in the ischemic cascade?
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pain
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what is the second to last thing to occur in the ischemic cascade?
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EKG changes
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why is the fibrous plaque important to ischemia?
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it can rupture
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which type of plaque is most dangerous and why?
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the newest plaques because they have the thinnest fibrous cap
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when is a plaque rupture most likely to occur?
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when subcapsular material that is heavily lipid laden and the fibrous cap is thin
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what is most likely to tear the fibrous cap?
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shear force at bifurcations and sharp vessel bends
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what type of platelet plug is the initiating feature?
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a white plug; not red (red indicated thrombin mediated)
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what is made simultaneously as fibrin?
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plasmin to lyse the thrombus
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why is dyspnea a presenting feature in angina?
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when heart stiffness increases, the pulmonary vascular pressure increases and the vascular bed gets congested and presents with dyspnea
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what is the most important factor of stable angina?
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it is predictable
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how can you differentiate between unstable and mixed angina?
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you must have a history of events
with mixed, variability is they key so that one day you might be fine but another day you might have the severe pain doing the same things |
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what type of angina requires the most aggressive therapy?
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creescendo angina
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why are arrythmias a result of ischemia?
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membrane potentials decrease
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who has the highest morbidity and mortality in ischemic heart disease?
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patients with diabetes and metabolic syndrome
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what 4 things should you first give to patients hospitalized for angina with an aggressive approach?
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IV nitrates
beta blocker anti-platelet therapy anticoagulant |
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what 5 things do you give to patients being treated in the hospital for angina with conservative care?
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IV heparin
nitro 2b3a inhibitor aspirin beta blocker |
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what 2 things are not needed in lower risk hospitalized ishcemic patients?
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heparin
NO thrombolysis |
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what 5 meds can be given to prevent angina?
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aspirin
beta blocker statin nitrates ACE inhibitors |
