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25 Cards in this Set
- Front
- Back
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Merkel Cell Carcinoma -who gets it -how common -where do cells arise -what does the tumor look like. |
Primary cutaneous neuroendocrine carcinoma. (Rare) occurs in fair skinned elderly pts. VERY MALIGNANT.
Arises from merkel cells located in basal layer of epidermis and hair follicles.
tumor is bluish red and grows rapidly. |
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Treatment of merkel cell carcinoma |
Wide local excision and prophylactic regional lymph node dissection. Post-Op radiation to tumor site and lymph node Chemo for metastasis
poor prognosis |
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Tumors of langerhans cells |
bone marrow derived dendritic cells that reside in the upper layer of epidermis.
most are benign but they can be aggressive. |
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Where do tumors of langerhans cells occur? |
Limited to one organ Most likely to be bone least likely to be CNS. |
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What does the skin look like in tumors of langerhans cells |
Brown to purplish papules (Hashimoto-Pritzker varient rash) in infants (least common)
Eczematous rash which looks like candida infection
oral lesions |
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Treatment single system of langerhans cells |
It depends on involvement and number of lesions.
Topical therapy for skin vs close observation with treatment upon progression. |
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Treatment of multi system langerhans cells |
chemotherapy for symptomatic patients or those at high risk
disease is incurable but may be indolent |
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Trichilemmoma -what do they look like -what syndrome can be associated -diagnosis/treatment |
Hair follicle tumor. Single or multiple small nodules on face and neck that look like warts.
Could be from Cowden's syndrome
Local resection will give diagnosis and be curative if malignant. |
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Trichoepithelioma -what is it/genetics -what does it look like -onset -treatment |
Hair follicle tumor. single (non-hereditary), multiple (AD). Discrete skin colored papules on nasolabial folds, eyelids, and central face. (don't confuse with basal cell carcinoma) onset at puberty local resection is curative. |
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Pilomatricoma -what is it -treatment |
Hair follicle tumors arising from hair matrix Can be single or multiple may invade ovally but does NOT metastasize
Local resection is curative |
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Fox-Fordyce Anomaly -what is it -where is it found -who gets it
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ectopic sebaceous glands Fordyce spots which are small yellow papules on vermilion border of lip or oral mucosa. increases with age and may be associated with Reiter's syndrome maybe associated. NOT MALIGNANT
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Sebaceous Carcinoma -who gets it -where -what does it look like -treatment |
conjunctiva of upper eyelid in women btw 60-80 Asians Can look like squamous cell or basal cell Slow growing but it is aggressive and can Metastasize.
Surgical removal and radiation. |
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Supernumerary nipple -what is it -where is if found
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apocrine gland tumor. extra nipple which develops along embyrologic milk lines
NEVER malignant remove surgically if problematic |
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Poroma -what is it -where is it found -treatment |
Benign tumor of eccrine gland outer cells of intraepidermal duct pedunculated and skin colored seen in sole and palm
surgical removal |
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Cylindroma (turban tumor) where does it come from? what does it look like? treatment? |
Benign tumor of intradermal coiled duct of eccrine gland. Multiple, firm, smooth, dome-shaped, movable, pink/red papules. Females Rarely progress to carcinoma surgical excisions |
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Clear Cell Carcinoma |
Solitary eccrine gland tumor of face, hand, head, or foot widespread matastases Differentiate primary vs secondary from skin mets (RCC) |
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Eccrine Adenocarcinoma |
ulcerating nodule poorly differentiated tumors which are highly malignant and may metastasize rapidly.
Differentiate from METS from other sites. |
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Cutaneous T-Cell Lymphoma (Mycosis Fungoides) -what is it -what is it associated with -treatment |
Low grade T-cell lymphoma
Strong association with CMV IgG
treated with topical nitrogen mustard, UVA, electron beam radiation |
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Sezary's syndrome |
when lymphoma cells from cutaneous T-cell lymphoma shed into blood.
This is not good. |
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Glomus Tumor -what are they -what do they look like -treatment? |
benign vascular tumor which mimics modified smooth muscle cells of glomus body (AV anastomosis which is in skin for temp regulation)
Small blue-red nodule in subcutaneous tissue or subungual regions of finger. can be painful.
Excision treatment. |
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Angiosarcoma -what is it -where is it found
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malignant tumors of blood or lymph vessels can be on face and scalp of old men can be at sites of previous radiation |
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Stewart-Treves Syndrome |
Cutaneous lymphangiosarcoma arising from chronically lymph edematous extremities
CLASSIC IN BREAST CA |
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classic type Kaposi's Sarcoma -what is it -who gets it -treatment |
Malignant vascular lesion in skin (mediterranean, and jews) Usually indolent but can METs to lungs and GI
Local excision. Radiation for large lesion |
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immunosuppressed type kaposi's sarcoma -who gets it -treatment |
HIV patients (and transplant/ congenital immunosuppression)
Surgical excision of small tumors if wide spread then chemo |
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Liposarcoma -when do you get it -treatment |
malignant fat tumor 55-60yo treated with aggressive surgery and skin grafts Radiation may be used chemo for mets |
