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5 Cards in this Set
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What's the best estimate of iron concentration of packed red blood cells?
A. 0.1 mg iron/unit pRBCs B. 0.2 mg iron/unit pRBCs C. 0.5 mg iron/unit pRBCs D. 1.0 mg iron/unit pRBCs E. 10 mg iron/unit pRBCs |
D. 1.0 mg Fe/unit pRBCs.
This is a good thing to remember for blood banking as well and very testable. The high iron content is why people with chronic hemolytic conditions, such as sickle cell disease, often develop very high Fe levels requiring chelation therapy. QCCP2, Iron deficiency anemia |
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What is the relationship between iron and lead levels in children?
A. no correlation B. increased iron, and increased lead independent of socioeconomic status C. decreased iron and increased lead independent of socioeconomic status D. increased iron and increased lead dependent on socioeconomic status E. decreased iron and increased lead dependent on socioeconomic status |
C. decreased iron and increased lead independent of socioeconomic status.
There is an inverse relationship between lead levels and iron levels, even when controlled for socioeconomic status. High lead levels inhibit intestinal absorption of iron, in addition to low iron facilitating lead uptake. QCCP2, Iron deficiency anemia |
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Where does intrinsic factor bind vitamin B12?
A. oral cavity B. stomach C. duodenum D. ileum E. jejunum |
D. ileum.
First, ingested B12 binds to a factor in the stomach where intrinsic factor is produced. It is not until the R Factor-B12 complex reaches the duodenum that R factor detaches and intrinsic factor binds, finally being absorbed in the ileum. QCCP2, B12 deficiency |
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Where in the body is folate absorbed?
A. oral cavity B. stomach C. duodenum D. ileum E. jejunum |
E. jejunum.
Unlike B12, folate is not efficiently stored by the body and must be ingested regularly, usually from leafy greens. Once ingested, it is absorbed by enterocytes in the jejunum. QCCP2, Folate and B12 |
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All of the following are features of megaloblastic anemia, except:
A. marked oval macrocytosis B. left-shifted leukocytosis C. decreased RBC count D. hypersegmented neutrophils E. large platelets |
B. left-shifted leukocytosis.
The WBC count is usually not elevated, much less left-shifted. There is a maturation arrest due to the lack of DNA precursors, which explains the hypersegmented neutrophils. This ineffective hematopoiesis leads to a bone marrow full of immature precursors. When these precursors lyse, there is an increase in LDH and bilirubin. QCCP2, Folate and B12 |
