Clinical Pathology Exam Ii

Front 1

Which 2 bone marrow neoplasms result in hypercalcemia?

Back 1

Multiple Myeloma
Lymphoma

Front 2

Bone marrow collection site in dog

Back 2

iliac crest
trochanteric fossa
proximal humerus

Front 3

Bone marrow collection site in cat

Back 3

trochanteric fossa
proximal humerus

Front 4

Bone marrow collection site in horse, cow

Back 4

rib
sternum
proximal humerus
iliac crest

Front 5

which BM collection method is best to rule out myelofibrosis or aplasia?

Back 5

Biopsy

Front 6

How many megakaryocytes in a BM smear are adequate?

Back 6

2-10 /smear on 10X

Front 7

How many lymphocytes are normal in bone marrow?

Back 7

< 10% in dogs
<15% in cats

Front 8

How many macrophages and plasma cells are normal in bone marrow?

Back 8

< 2%

Front 9

M:E for dog

Back 9

1-2: 1

Front 10

M:E for cat

Back 10

1.3-3 :1

Front 11

M:E horse

Back 11

0.5-2.4 :1

Front 12

M:E cow

Back 12

0.5-0.6 : 1

Front 13

True/False. Hemosiderin in bone marrow is normal in dogs.

Back 13

True

Front 14

BM iron is increased/decreased with inflammation, and increased/decreased with iron deficiency.

Back 14

inflammation- increased
deficiency- decreased

Front 15

What is the criteria for aplasitc anemia on BM biopsy?

Back 15

< 25% hematopoietic tissue

Front 16

Which drugs can cause aplastic anemia?

Back 16

Estrogen
Chloramphenicol
Griseofulvin
methimazole
albendazole

Front 17

This plant can cause aplastic anemia in ruminants

Back 17

Bracken fern

Front 18

Myelodysplastic syndrome is one cause of what peripheral abnormality

Back 18

Pancytopenia

Front 19

True/False. In myelodysplastic syndrome, > 30% of nucleated cells are balsts.

Back 19

False. That would be acute leukemia. Myelodysplastic syndrome is characterized by < 30% blasts in BM

Front 20

Would a degerative left shift in neutrophils correlate to an increased in myeloid cells in BM or decrease?

Back 20

Decrease- stores are depleted and immature cells are being released

Front 21

Lymphomas are graded based on which criteria?

Back 21

mitotic rate
arrangement of tissue

Front 22

True/False. Most canine lymphomas are high grade/diffuse neoplasms

Back 22

True

Front 23

Hypercalcemia is more often seen in lymphomas of what cell origin?

Back 23

T cell

Front 24

What does stage II lymphoma indicate?
III?

Back 24

regional nodes involved
generalized lymphadenopathy

Front 25

Stage IV lymphoma?

Back 25

liver and spleen involvement

Front 26

What is the most common cause of hematopoietic tumors in cats?

Back 26

FeLV

Front 27

True/False. FeLV increases risk 5- fold of B cell lymphoma.

Back 27

False. FIV does.

Front 28

Which conditions could cause false positive for lymphoma PCR?

Back 28

E. Canis and immune mediated disease result in significant monoclonal stimulation.

Front 29

CD3 lymphocytes are

Back 29

T lymphocytes

Front 30

CD79a and CD20 are

Back 30

B lymphocytes

Front 31

CD34

Back 31

Acute leukemia lymphoblasts

Front 32

One diagnosis of suspicion with a CBC with increased NRBCs but no polychromasia

Back 32

Acute myeloid leukemia- due to asynchronous maturation of cytoplasm and nucleus

Front 33

Lymphocytosis above 25,000 in dogs and 40,000 in cats raises index of suspicion for which disease?

Back 33

Chronic Lymphocytic Leukemia

Front 34

What do you expect to find on BM aspirate in an animal with chronic myeloid leukemia?

Back 34

You wouldn't use BM aspirate in this case- can't differentiate from severe inflammation

Front 35

Bence-Jones proteins in urine are indicative of what disease?

Back 35

Multiple myeloma

Front 36

True/False. Plasmacytomas are usually functional, whereas multiple myelomas are rarely functional.

Back 36

False.

Front 37

True/False. Cats with alimentary lymphoma tend to be FeLV negative.

Back 37

True. There may be an association with FIV.

Front 38

What leukemia type can cause profound nonregenerative anemia?

Back 38

M6 (erythroleukemia)

Front 39

True/False. CD3 can help differentiate lymphoma from acute leukemia if blasts are present in both tissues and marrow.

Back 39

False. CD34 is found on stem cells, used to identify acute leukemia in bone marrow.

Front 40

Which enzyme assay may differentiate between AML and ALL?

Back 40

Myeloperoxidase

Front 41

CD 68

Back 41

Macrophages

Front 42

True/False. Myelophthisis is common with chronic lymphocytic leukemia.

Back 42

False.

Front 43

Differentials for big "blasty" cells

Back 43

Antigenic stimulation
Lymphoma stage V
ALL
AML

Front 44

Differentials for pancytopenia?

Back 44

ALL
AML
Stage V lymphoma
multiple myeloma

Front 45

True/False. Plasmacytoma is often malignant in skin, benign in hematopoietic tissue.

Back 45

False.

Front 46

Do multinucleate plasma cells necessarlily make them malignant?

Back 46

No, particularly not in skin plasmacytomas

Front 47

Which epithelial cell tumors are found in grape-like clusters, have high N:C?

Back 47

Basal cell

Front 48

Rusell Bodies

Back 48

found in variants of plasma cells called Mott cells, are accumulations of IgM

Front 49

Which tumor has prominent nuclei and is the cell that looks back at you?

Back 49

Melanoma

Front 50

Significance of NRBCs in spleen?

Back 50

Extramedullary hematopoiesis

Front 51

Why must one be careful diagnosing lymphoma in spleen FNA?

Back 51

Large germinal centers, if aspirated, look like lymphoma when actually just reactive.

Front 52

Birnavirus

Back 52

Infectious bursal disease

Front 53

circovirus

Back 53

psitticine beak and feather disease

Front 54

Enlarged spleen with boxcar bacilli.

Back 54

Anthrax

Front 55

Virus causes splenic infarct.

Back 55

Hog cholera aka classical swine fever

Front 56

Granulomatous splenitis is seen in what animals?

Back 56

Birds

Front 57

Oncogenesis of what virus is attributed to Tax protein?

Back 57

Bovine Leukosis Virus

Front 58

Lymphoma in chickens is associated with what virus? What does it look like?

Back 58

Marek's disease
Enlarged sciatic nerve

Front 59

Normal cell count in synovial fluid of dog

Back 59

< 3000

Front 60

Normal cell count in synovial fluid of cat and cow

Back 60

< 1000

Front 61

Normal cell count in synovial fluid of horse

Back 61

< 500

Front 62

Non-inflammatory joint effusion cell counts

Back 62

< 5000
5-10% neutrophils

Front 63

Mild, mixed inflammatory joint effusion cell count

Back 63

< 10,000
10-15% neutrophils

Front 64

Suppurative inflammatory joint effusion cell count

Back 64

> 10,000
40-100% neutrophils

Front 65

Most common neoplasm of the joint in the dog

Back 65

Histiocytic sarcoma

Front 66

Clinical pathology for uroperitoneum.

Back 66

Elevated fluid creatinine
Elevated K+ in fluid

Front 67

Fluid cell counts for fluid analysis are most important for distinguishing what?

Back 67

Exudates from modified transudates
inflammation vs neoplasm

Front 68

Total protein in fluid analysis is important for distinguishing what?

Back 68

transudate from modified transudate

Front 69

Transudate

Back 69

Protein < 2
Cells
< 1500 dogs
<5000 large animal

Front 70

Causes of transudate?

Back 70

Hypoalbuminemia
increased hydrostatic pressure
Uroperitoneum

Front 71

Fluid with TP >2-2.5, cell count 3000-5000.

Back 71

Modified Transudate