Clinical Pathology

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acanthocyte

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red blood cell with multiple variably sized irregular membrane projections that are caused by alterations in the ratio of membrane cholesterol to phospholipid

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antibodies

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type of protein produced against antigens by the immune system

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agglutination

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clumping of red blood cells that is usually caused by cross-linking of red blood cell surface-associated antibodies

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anemia

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white blood cell that does not contain secondary granules.

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anisocytosis

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variation in which hemoglobin, packed cell volume, and red blood cell count decrease below normal reference range

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antigen

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substance that can cause immune system to produce antibodies

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anticoagulant

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substance that prevents the clotting of blood

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azurophil granules

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cytoplasmic granules that stain pink to reddish-purple with wright's stain

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azurophil monocyte

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monocyte of reptiles that contains many fine dust-like sytoplasmuc azurophilic granules

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band cell

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type of white blood cell with nuclear membrane that has parallel sides

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bar cell

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red blood cell with a central bar-shaped outfolding known as knizocyte

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basophil

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white blood cell of granulocytic lineage with a segmented nucleus, purple cytoplasm and often purple cytoplasmic granules

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basophilia

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reaction of cell to wrights stain resulting in a bluish-stained cytoplasm

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basiphilic

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bluish color on wrights stained preparations refered to as basophil

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binucleation

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containing 2 nuclei

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blister cell

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red blood cell with a membrane vacuole

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bone marrow

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central portion of long flat and irregular bones that is principal site of hematopoiesis

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buffy coat

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layer of white blood cells and platelets that collects immediaetly above red blood cells in centrifuged whole blood;whitish apperance

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burr cell

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oval to elongated red blood cell with multiple fine projections

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chelonian

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term used to refer to turtles tortoises or terrapins

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chromatin

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copmlex of DNA and nuclear proteins

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codocyte

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red blood cell with an extra round outfolding of membrane in the middle of the cell that gives target like appearance;known as target cell

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crenation

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an in vitro artifact that results in formation of red blood cells with multiple uniform small fine projections on cell membrane

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cytoplasm

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portion of cell that is exclusive of the nucleus

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cytochemical

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staining technique to identify cell types

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dacryocyte

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teardrop shaped red blood cell that may be seen in animals with myelofibrosis

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deoxyribonucleric acid (DNA)

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nucleic acid that contains basic genetic information found in nuclei of cells

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diff-quick

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commercially available preparation for manually staining slides with modifies wrights stain

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disseminated intravascular coagulation (DIC)

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pathophysiological state that may develop as a result of damage of endothelial cells;severe life threatening bleeding abnormalities

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dohle body

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small round to irregular blue structure in cytoplasm of cells of neutrophilic lineage

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dyserythropoiesis

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myelodysplasia of cells of the erythrocytic lineage

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dysgranulopoiesis

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myelodysplasia of cells of the granulocytic lineage

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dysthrombopoiesis

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myelodysplasua of platelets

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eccentrocyte

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red blood cell with a cresent-shaped clear area that is eccentrically placed

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echinocyte

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red blood cell with multiple small delicate regular shaped spines distributed evenly around the membrane

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eosinophil

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white blood cell of the granulocytic lineage with reddish to reddish orange granules in the cytoplasm

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erythrocyte

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mature red blood cell

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erythropoiesis

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production of red blood cells

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ethylenediaminetetraacetate (EDTA)

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anticoagulant most commonly used for collection of blood for hematological examination

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extracellular

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located outside cell

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formalin

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liquid used for preservation of tissues

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ghost cell

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remnant membrane of red blood cell

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granulocyte

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white blood cell that contains secondary cytoplasmic granules

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granulopoiesis

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production of granulocytes

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heterophil

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granulocytic white blood cell that contains many orange to red elongated to rod shaped granules in the cytoplasm

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heinz body

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rounded often refractile projection from the surface of the red blood cell that is a result of oxidation and denaturation of hemoglobin

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hematocrit

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percentage of red blood cells relative to plasma

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hematopoiesis

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production of blood cells

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hemoglobin

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protein in red blood cells that carries oxygen

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hemosiderin

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insoluble form of iron that appears as golden brown to black granular to globular material