Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
|
What causes rbc hemolysis in immune hemolytic anemia? |
coating on erythrocyte membrane with antibodies or complement |
|
|
Which immunoglobulin causes warm agglutinin disease? |
IgG |
|
|
What immunoglobulin causes cold agglutinin disease? |
IgM |
|
|
Besides immunoglobulins, what is the main difference between warm and cold autoimmune hemolytic anemia? |
In warm autoimmune hemolytic anemia, the maximal antibody binding occurs at warm temperatures (body temperature); in cold automimmune hemolytic anemia, maximal antibody binding occurs at cold temperatures |
|
|
What is a Direct Coombs test testing for? |
agglutination that demonstrates the presence of antibodies or complement on patient's RBCs |
|
|
What soes an Indirect Coombs test test for? |
agglutination that tests for antibody in patient serum |
|
|
Which is the most common form of the sickle syndromes? |
Sickle Cell Disease |
|
|
What gentic mutation causes sickle cell disease? |
substitution of valine for glutamic acid in the 6th amino acid of the beta-globulin gene |
|
|
In which populations are you most likely to find sickle cell disease? |
African, Indian, Mediterranean, or Middle eastern populations |
|
|
What conditions can stimulate sickling of RBCs in sickle cell disease? |
1. changes in cellular hydration/ dehydration 2. changes in oxygen tension (hypoxia, acidosis, high altitude) |
