Clinical Immunology

Front 1

_________ are the IgE (antibody) immune responses to harmless antigens

Back 1

Allergies

Front 2

When the immune response is the cause of the disease we call it ___________.

Back 2

Hypersensitivity

Front 3

Hypersensitivities, other than allergies, are caused by ____ or by ____ or ___ activities.

Back 3

IgG, Th1, Tc

Front 4

________ reactions occur against self antigens.

Back 4

Autoimmune

Front 5

How many types of hypersensitivity reactions are there?

Back 5

4

Front 6

Type 1 is a ________________ reaction.

Back 6

anaphylactic

Front 7

Type 1 takes ______________ to manifest.

Back 7

under 30 minutes

Front 8

In Type 1 hypersensitivity, the antibody ______ binds to mast cells or basophils;causing degranulation (histimines and leukotrienes released)

Back 8

IgE

Front 9

Common examples of Type 1 Hypersensitivity are?

Back 9

anaphylactic shock from drug injections, insect venom, hay fever, asthma

Front 10

Type 2 hypersensitivity is called _________.

Back 10

cytotoxic

Front 11

Type 2 takes ___________ to manifest.

Back 11

5-12 hours

Front 12

In type 2 hypersensitivity, antigen causes formation of ____ and _____ that bind to target cell; when combines with action of complement, ______ the target cell(RBC). Also activates ADCC (macrophages or NK cells bind antibody-coated RBC's and kill them).

Back 12

IgM, IgG, destroys/lyses

Front 13

Common examples or type 2 hypersensitivity are?

Back 13

Transfusion reactions, Rheumatic fever and Rh incompatibility

Front 14

Type 3 hypersensitivity is called __________________.

Back 14

an immune complex

Front 15

Type 3 takes ______________ to manifest.

Back 15

3-8 hours

Front 16

In type 3 (immune complex), antibodies and antigens form ________________________.

Back 16

complexes that form damaging inflamation.

Front 17

Common examples of type 3 hypersensitivity are?

Back 17

arthus reactions(damage to bld vsls, heart, lungs, joints, skin, kidneys), Lupus and serum sickness

Front 18

Type 4 hypersensitivity is called_______________________.

Back 18

cell-mediated or delayed-type

Front 19

Type 4 takes ___________ to manifest.

Back 19

24-48 hours

Front 20

In type 4 (cell-mediated/delayed-type), antigens cause formation of _____ that ________________.

Back 20

Tc that kill targeted cells

Front 21

Common type 4 reactions are?

Back 21

transplant tissue rejection, contact dermititis, TB,chronic asthma, type 1 diabetes

Front 22

Are you allergic the first time you are exposed to something?

Back 22

No

Front 23

______ ______ is the inflamation throughout circulation that can lead to death.

Back 23

Systemic anaphylaxis

Front 24

The most common effects of allergic mediators are?

Back 24

the things that make us miserable (headache, runny nose, sneezing, wheezing, itchy eyes)

Front 25

______________ is basically: if your invironment is too clean (no or little helminths) you will have mare allergies.

Back 25

Hygene hypothesis

Front 26

A___________ drug blocks the plasma cell production of IgE and Inhibits Tcells.

Back 26

Corticosteroid

Front 27

A _____________ drug acts on the surface of mast cells, preventing granulation.

Back 27

Cromolyn

Front 28

A ___________ drug couteracts the effects of cytokines on targets (bronchiole/mucus production).

Back 28

Antihistimine

Front 29

Organ grafts: host ________ kills cells in fraft with ________________.

Back 29

Tcells, foreign MHCI and II(foreign to the host)

Front 30

Bone Marrow Transplant: mature _____ ____ in graft kill cills in host with _________________.

Back 30

Tcells, Foreign MHCI and II (foreign to the bone marrow)

Front 31

___________ are multiple genes that are responsible for the same thing.

Back 31

Allels

Front 32

We have ____ different Class I and _______ different Class II MHC proteins (each with many allels); making tissue typing for transplants time consuming or time prohibitive.

Back 32

~ 6, ~ six

Front 33

Anti-rejection Drugs do 2 things: ____________ _______ and _____ _______ ________.

Back 33

block inflammation, block Tcell activity

Front 34

The anti-rejection drug that blocks inflammation is/are ______.

Back 34

Corticosteroids

Front 35

The anti-rejection drug that block Tcell activity is/are_____ and ______.

Back 35

Cyclosporine A and Monoclonal antibodies

Front 36

Autoimmunity is often triggered by an _____________.

Back 36

Infection

Front 37

________ ________ is the immune response to a pathogen antigen generates antibodies and T cells that also bind to self antigens.

Back 37

Molecular mimicry

Front 38

Type I diabetes is caused by this virus.

Back 38

Coxsackie

Front 39

________ are destroyed by anti-virus T cells because they closely match the Coxsakie antigen the T cells are going after.

Back 39

peptides on islets

Front 40

Immune Deficiencies are ________.

Back 40

inborn(usually durring cell development or gene mutation for an essential protein)

Front 41

_______ immune deficiencies are usually due to microbe __________ factors. An example would be ________.

Back 41

virulence, AIDS

Front 42

David the "Bubble Boy" had _____(no T or B cells)

Back 42

SCID

Front 43

David died from cancer caused by epstein barr virus when he recieved a _______________ from his sister.

Back 43

Bone Marrow Transplant (to save his life)