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3 Cards in this Set
- Front
- Back
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Gilbert syndrome |
-Increased indirect bilirubin due to inability to conjugate -patients with gilbert syndrome have reduced UGT activity (30% of normal) |
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What is the spectrum of severity of UGT disorders? What will lab levels show |
This is hyperbilirubinemia with absence of any other lab abnormalities Mild- Gilbert syndrome (30% activity UGT) Crippler-Najjar type 1 syndrome-- absence of activity |
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Dubin Johnson syndrome |
Isolated direct hyperbilirubinemia defect in MRP2 transporter that excretes conjugated bilirubin into bile duct |
