Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
16 Cards in this Set
- Front
- Back
|
T/F HL is less common than Non-HL
|
False - non-hodgkin's is more common
|
|
|
Hodgkin Lymphoma age distribution
|
bimodal age distribution - 20s and 65s
|
|
|
Hodgkin L vs non-Hodgkin L clinical presenation
|
HL:
contiguous spreading from node to node rare involve CNS, skin tract splenomegaly rare NHL Less predictable pattern for spread involves all organs splenomegaly possible |
|
|
Hodgkin L or non-Hodgkin L is more associated with infection
|
non-hodgkin lymphoma is more associated with infeciton
H pylori - gastric MALT lymphoma EBV - burkitt's Hep C - indolent NHL (marginal zone lymphoma) HTLV-1 Adult T cell leukemia |
|
|
staging of Non Hodgkin Lymphoma (Ann Arbor)
|
1 - single LN region
2 - more than 2 LN regions on same side of diaphragm 3 - LN regions on BOTH side of diaphragm 4 - multifocal infolvement of >1 extralymphatic site (like in an organ) + A category - no consitutional symptoms B category - fever, night sweat, 10% weight loss |
|
|
factors that influence treatment of non-hodgkin lymphoma
|
APELS
Age (> 65) LDH (2x normal) Performance Status Extranodal involvement Stage |
|
|
chemotherapy for diffuse large B cell lymphoma
|
CHOP
Cytoxan Hydroxydaunomycin Oncovin Prednisone |
|
|
Rituximab
|
antibody against CD20 - use against B-cell lymphoma
might activate hep b |
|
|
low grade NHL
|
incurable
follicular lymphoma and small lymphocytic lymphoma |
|
|
radioimmunotherapy
|
radioactive neucleotides attached to antibodies specific to the tumor
lowers exposure of healthy tissue, concentrates effect |
|
|
tumor lysis syndrome
|
oncologic emergency - tumor cells lyse spontaneously or trigger with therapy
increased potassium, phosphate, uric acid -> renal failure and hypocalcemia |
|
|
MALT lymphoma of Gastric Mucosa
|
H Pylori associated
treat with PPI, amoxicilin, clarithromycin |
|
|
prognostic factors for hodgkin lymphoma
|
APELS
+ gender (male) + albumin (low) + lymphocyte (low) |
|
|
Types of Hodgkin Lymphoma
|
Nodular sclerosis
Mixed cellularity Lymphocyte rich Lymphocyte depleted |
|
|
treatment for Hodgkin Lymphoma
|
Adriamycin
Bleomcyin Vinblastine Dacarbazin all IV - total compliance less myelotox no infertility no leukemia |
|
|
Stage of Hodgkin Disease
|
Ann arbor stage
bulkiness of disease (mediastinal mass size) presence of B symptoms |
