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15 Cards in this Set
- Front
- Back
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Acute Leukemia
Presentations (6) |
1. anemia
2. thrombocytopenia 3. neutropenia 4. leukostasis (AML) 5. tumor lysis syndrome (release of blast content: uric acid, phosphate, K) --> renal problems 6. DIC (APML) - blasts release procoagulants, clotting cascade, consume clotting factors --> severe bleeding |
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What are the bad leukemias
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1. secondary AML
2. philadephia + ALL 3. elderly AML hard to cure |
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AML Drugs
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1. cytarabine
2. anthracyclines 3. ATRA |
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ALL Drugs
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1. Vincristine
2. Corticosteroids 3. Anthracyclines |
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Supportive Care
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1. Allopurinol
2. Transfusions 3. Growth factors 4. Antibiotics 5. BM transplant (most aggressive, toxic) |
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Phases & Goals of Acute Leukemia Treatment (4)
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1. Induction (remission, reduce #)
2. Consolidation 3/ Maintenance 4. BM Transplant (worst cases) |
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How does APML present?
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1. fatigue
2. nosebleed 3. petechiae 4. DIC |
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Lymphomas
Presentation (6) |
1. ^lymph nodes
2. ^liver, spleen 3. ^LD, cytopenia 4. B-symptoms 5. SVC syndrome 6. tumor lysis syndrome (Burkitt) |
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Ann Arbor lymphoma stages (4)
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I - one group of LN
II - two groups of LN, SAME side of diaphragm III - at LEAST two groups, BOTH sides of diaphragm IV - other organs (liver, BM) |
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Lymphoma Chemo treatments (4)
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1. alkylators
2. anthracycline 3. vinca 4. corticosteroids |
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Lymphoma:
Monoclonal Ab |
Rituximab (B-cell, CD20)
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Hodgkins lymphoma
Treatment |
chemotherapy (ABVD regiment)
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DLBCL
Treatment |
chemotherapy (CHOP regimen) + radiation
- Rituximab |
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What is blast crisis
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CML
- accumulating additional mutations makes SC no longer able to differentiate |
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CML treatment
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1. SC transplant (toxic)
2. Imatinib (newer) |
