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33 Cards in this Set
- Front
- Back
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what is the smith ab specific for?
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lupus
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what is a disorder of disorganized antibodies?
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lupus
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what specific blood test is important for lupus?
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titers
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what can misdiagnose lupus and why?
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dandruff because it looks like one of the diagnostic criteria, the malar rash
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what are a malar rash, discoid rash, photosensitivity, oral ulcers, arthritis, and renal disorders indicative of?
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lupus
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what is the SEAT of the discoid rash of lupus?
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Scaly
Erythematous Atrophy centrally Telangiectasia |
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when you see multi-tissue involvement in lupus, what should you think?
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vasculitis
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what is the worst lesion involving the kindey?
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diffuse proliferative GN
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what types of SLE patients will not respond meds and therefore must wait until they go into renal failure to be put on the transplant list?
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sclerotic
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how do you establish a drug-induced SLE dx?
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stop the drug and see if symptoms resolve
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who does neonatal lupus affect?
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children born of mothers with anti-ro or la antibodies
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what is a serious, permanent complication of neonatal lupus?
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complete heart block
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what generally defines primary reynauds?
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the longer you've had symptoms that can't be explained by anything else
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what are 3 things secondary reynauds be due to?
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CT disease
drugs and toxins structureal arterial disease |
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if a patient has persistent reynauds rather than intermittent, what can it be?
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scleroderma progressive systemic sclerosis
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what can sclerodactyly be a sign of?
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scleroderma progressive systemic sclerosis
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what are the hallmarks of scleroderma progressive systemic sclerosis?
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microangiopathy and fibrosis of the skin and visceral organs
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who is more likely to have severe progressive systemic sclerosis?
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blacks
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what is a fibroblast metabolic defect that includes collagen?
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scleroderma progressive systemic sclerosis
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what can cardiac involvement in scleroderma look like?
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myocardial fibrosis, cardiomyopathy
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what is the primary cause of morbidity and mortality in scleroderma?
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pulmonary involvement
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what can musculoskeletal involvement in scleroderma look like?
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myalgias and arthralgias
inflamed, non-erosive arthritis |
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if a patient regurgitates food, has constipation and paradoxical diarrhea, what does it indicate?
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GI involvement in scleroderma
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what does digital pitting, ulcerations, and dry gangrene indicate?
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vascular involvement in scleroderma
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what organ involvement occurs early in scleroderma with hemolytic anemia?
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renal involvement
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what presents initially as an inflammatory response with puffiness or swelling of hands and fingers but later presents as an induration of the skin that progresses proximally?
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cutaneous involvement in scleroderma
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what are 3 serologic abnormalities in scleroderma?
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ANA+
anti-Scl 70 antibodies anti-centromere bodies |
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what is a major criteria for scleroderma?
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skin thickening/induration proximal to MCP joints
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what are 3 minor criteria for scleroderma?
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sclerodactyly
digital pitting scars bibasilar pulmonary fibrosis |
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what Rx can be used for ischemic ulcers in scleroderma?
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calcium channel blockers for vasodilation
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CREST syndrome describes what?
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limited scleroderma
Calcinosis Raynaud's phenomenon Erythema Sclerodactyly Relangectasia |
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what is type I of inflammatory muscle disease?
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polymyositis in adults
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what are 4 typical dermal features that differentiate between polymyositis and dermatomyositis?
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grottens patches
heliotrope periungal erythema v-neck erythema |
