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30 Cards in this Set
- Front
- Back
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_______ includes arthritis, autoimmune diseases, some metabolic bone disease, fibromyalgia and others
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rheumatology
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most diseases include two processes
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autoimmunity and inflammation
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two non-inflammatory conditions are:
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osteoarthritis and fibromyalgia
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cytokines are proteins released by cells of the immune system and make cells ____
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move
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many meds used to treat autoimmune diseases work on
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cytokines
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_____ of the immune system leads to tissue damage through inflammation
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activation
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macrophages, white cells and complement and enzymes cause tissue death and this causes ________
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inflammation
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acute inflammation is a _____ process
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healing
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acute phase reactants will go up if have severe illness or trauma :labs show an increase in: ____ ____ _____
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CRP, ESR and WBC
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_____ effects in inflammation is why we feel sick
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systemic
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chronic inflammation releases _____ that cause scar formation and more damage
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cytokines
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HLA-DR4 is the gene that increases risk of
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rheumatoid arthritis
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HLA's are markers of self versus ___ self
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non
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Marjan's HLA's are ______ from Sani's HLA's
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different
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women get ____ autoimmune diseases then men
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more
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There are 3 MAJOR groups of drugs: ____ ___ ____
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steroids, immunosuppresants and biologic treatments
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TNF is
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tumor necrosis factor
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_______ in the joint fluid is diagnostic
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crystals
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WBC's < 200 is
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normal
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<3000 WBC's is
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non inflammatory
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3,000-50,000 WBC in joint fluid is
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inflammatory and could be infected
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>50,000 WBC's in joint fluid is
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infected
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pauciarticular means
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fewer than 5 joints
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_______ send out cytokines
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Leukocytes
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There are ___ types of hypersensitivity responses
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4
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Type I hypersensitivity
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allergy
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Type II hypersensitivity
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humoral immune function
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Type III hypersensitivity
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immune complexes
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Type IV hypersensitivity
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delayed sensitivty - cell mediated
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During the development (late fetal early prenatal period) of the immune system in children the system thinks "everything that is here belongs to me" . so if they are exposed to ______ early on makes them immune
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antigens. (Tolerance occurs before first month of life)
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