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9 Cards in this Set
- Front
- Back
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What are the four diseases caused by clonal proliferation of hematopoietic stem cells?
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chronic myeloid leukemia
myelofibrosis polycythemia rubra vera essential thrombocythemia |
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_ is caused by a clonal proliferation of hemotopoietic stem cells-they release growth factors, esp. platelet derived GF and cytokines resulting ina characteristic polyclonal marrow fibrotic rxn.
-polycythemia rubra vera -myelofibrosis -essential thrombocythemia |
myelofibrosis
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the typical age of presentation of myelofibrosis is ??
-50's -60's -70's |
60's
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_ is a clonal stem cell disorder in which the RBC mass is high and half of the pt's have an inc. platelet and/or WBC count.
-thrombocythemia -polycythemia rubra vera -myelofibrosis |
polycythemia rubra vera
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The clinical features of anemia, splenomegaly (massive), weight loss and fever are typical of what myeloproliferative disease?
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myelofibrosis
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A 'dragging' sensation of the LUQ is found in ?
-myelofibrosis -polycythemia rubra vera -thrombocytopenia -chronic liver disease |
myelofibrosis
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which disease is a clonal stem cell disorder that is typically found in the 50's, men are affected slightly more than women in which the RBC is high, and 1/2 of pt's also have a high plt and WBC count and that 40% have a marrow karyotypic abnormality?
-myelofibrosis -polycythemia rubra vera -thrombocythemia |
polycythemia rubra vera
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what drug can be used to treat the high WBC count of myelofibrosis?
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hydroxyurea
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'tear-drop' red blood cells and immature wbc's is found in what myeloproliferative disorder?
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myelofibrosis
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