Clin Dx Lab 2 - Mycology

Front 1

Superficial mycoses

Back 1

Pityriasis (Tinea) Versicolor

Front 2

Malassezia furfur

Back 2

Pityriasis (Tinea) Versicolor

Front 3

Hyperpigmented, well-demarcated, scaling lesions

Back 3

Pityriasis (Tinea) Versicolor

Front 4

Mantle distribution (shoulders, upper trunk, arms)

Back 4

Pityriasis (Tinea) Versicolor

Front 5

Dx of Tinea Versicolor

Back 5

KOH prep (H&E, PAS stains), Fungal culture (olive oil), Wood's lamp

Front 6

Tx of Tinea Versicolor

Back 6

Anti-dandruff shampoo

Front 7

Cutaneous mycoses

Back 7

Tinea

Front 8

Keratinophilic & keratinolytic

Back 8

Tinea

Front 9

Classic ringworm pattern

Back 9

Tinea

Front 10

Capitis, corporis, barbae, cruris (spares the scrotum), pedis, unguium

Back 10

Tinea

Front 11

Dx of Tinea

Back 11

KOH prep, Calcofluor white, Dermatophyte testing medium, or CX

Front 12

Tx of Tinea

Back 12

Skin - topical agents (miconazole, clotrimazole, terbinafine), Hair & nails - oral agents (griseofulvin, fluconazole, terbinafine)

Front 13

Subcutaneous mycoses

Back 13

Sporotrichosis

Front 14

Sporothrix schenckii

Back 14

Sporotrichosis

Front 15

Garderners & greenhouse workers

Back 15

Sporotrichosis

Front 16

Frequently result from punctures with splinters or thorns

Back 16

Sporotrichosis

Front 17

Def. dx for Sporotrichosis

Back 17

Culture

Front 18

Subcutaneous nodule into necrotic ulcer - Follows lymphatics

Back 18

Sporotrichosis

Front 19

Tx for Sporotrichosis

Back 19

Oral potassium iodide (localized), Amphotericin B (disseminated/recurring)

Front 20

Systemic mycoses

Back 20

Histoplasmosis, Coccidioidomycosis, Cryptococcus neoformans, Blastomyces dermatidis

Front 21

Bird & bat feces

Back 21

Histoplasmosis

Front 22

Ohio & Mississippi river valleys

Back 22

Histoplasmosis

Front 23

cultures require 4 to 6 weeks, DNA probes provides ID in 1 to 3 weeks, sputum is positive in only 10 to 15 % of acute pulmonary disease cases, serology- complement fixation antibodies (1:32 titers)-75-95 % will be positive 6 weeks after exposure

Back 23

Histoplasmosis

Front 24

Histoplasma antigen detected by RIA in urine or serum samples (esp if immunodeficient)

Back 24

Histoplasmosis

Front 25

Inhalation of spores, spread through blood & lymphatics

Back 25

Histoplasmosis

Front 26

Chronic cavitary pulmonary disease that mimics TB

Back 26

Histoplasmosis

Front 27

Tx of Histoplasmosis

Back 27

Amphotericin B

Front 28

Southwest US

Back 28

Coccidioides Immitis

Front 29

Transmitted by inhaled spores

Back 29

Coccidioides Immitis

Front 30

Erythema nodosum and erythema multiforme or symmetrical arthritis possible

Back 30

Coccidioides Immitis

Front 31

Great immitator - may look like syphilis or TB

Back 31

Coccidioides Immitis

Front 32

Labs = dec'd WBCs, eosinophilia, elevated ESR

Back 32

Coccidioides Immitis

Front 33

Tx for Coccidioides Immitis

Back 33

Most resolve w/o therapy

Front 34

Pigeon droppings (ubiquitous in soil)

Back 34

Cryptococcus Neoformans

Front 35

Only pathogenic fungus to form a capsule

Back 35

Cryptococcus Neoformans

Front 36

HIV pt with CD4 < 100

Back 36

Cryptococcus Neoformans

Front 37

India ink, cryptococcal antigen in blood or CSF, postive culture

Back 37

Cryptococcus Neoformans

Front 38

CSF with elevated WBC & protein, low glucose

Back 38

Cryptococcus Neoformans

Front 39

Tx for Cryptococcus Neoformans

Back 39

Amphotericin B or Diflucan (not as effective but better tolerated)

Front 40

White circles with central clearing

Back 40

Cryptococcus Neoformans

Front 41

Soil & leaf litter

Back 41

Blastomyces Dermatidis (Gilchrist's Disease)

Front 42

Dogs & cats

Back 42

Blastomyces Dermatidis (Gilchrist's Disease)

Front 43

Pulmonary, cutaneous, or systemic

Back 43

Blastomyces Dermatidis (Gilchrist's Disease)

Front 44

Specific fluorescently labeled antibody react with histologic tissue sections

Back 44

Blastomyces Dermatidis (Gilchrist's Disease)

Front 45

Soil, air, decaying matter

Back 45

Aspergillosis

Front 46

Allergic Reactions

Back 46

Aspergillosis

Front 47

Superficial cutaneous infections, limited invasive infections

Back 47

Aspergillosis

Front 48

Frankly invasive pulmonary infection

Back 48

Aspergillosis

Front 49

Prevention with filtered air

Back 49

Aspergillosis

Front 50

Tx of Aspergillosis

Back 50

Amphotericin B

Front 51

4th most common cause of nosocomial (HOSPITAL) bloodstream infection

Back 51

Candidiasis

Front 52

C. albicans most common

Back 52

Candidiasis

Front 53

In GI tract, vagina, skin, & nails (diaper dermatitis, vaginitis)

Back 53

Candidiasis

Front 54

IV lines, in-dwelling caths

Back 54

Candidiasis