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75 Cards in this Set
- Front
- Back
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Diffuses into extravascular spaces
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IgG
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Can cross placenta
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IgG
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Can activate complement
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IgG
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Pentamer - large size
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IgM
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Limited to intravascular areas
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IgM
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Acute disease
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IgM
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In secretions
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IgA
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Surface of B lymphs in association with IgM
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IgD
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Elevated in hypersensitivity reactions, allergies, parasitic infections
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IgE
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Basophils - histamine & heparin
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IgE
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IgE-mediated
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Type 1
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RAST
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Type 1
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Cytotoxic/cell-mediated
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Type 2
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Free Ab reaction with Ag associated with cell surfaces
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Type 2
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ABO transfusion reactions
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Type 2
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Immune complexes
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Type 3
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Decrease in C3, C4, C50
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Type 3
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Delayed hypersensitivity (24-48 hours after exposure)
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Type 4
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Contact dermatitis
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Type 4
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PPD screening
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Type 4
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Looking for antigen
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DFA - chlamydia testing, legionella
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Looking for antibody
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IFA - ANA, FTA-ABS
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Measure concentration, sensitive, detects trace amounts (T3, T3, TSH, B-HCG)
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RIA
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Latex coated with antigen to look for antibody
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Latex aggultination
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Latex agglutination
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Monospot, strep screen
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Clumping of particles to form visible masses
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Flocculation
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Flocculation
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RPR
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ANA
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Collagen, rheumatic, connective tissue disease, mainly to screen for SLE
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Anti-tissue necrosis
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Crohn's disease
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Anti-gliadin
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Celiac's disease
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Anti-endomysial
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Celiac's disease
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Anti-tissue transglutaminase
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Celiac's disease
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Deaminated gliadin peptide
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Celiac's disease
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Homogenous ANA
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SLE
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Nuclear rim ANA
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SLE
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Speckled ANA
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SLE, Sjogren's, RA, polymyositis, mixed ct disease
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Nucleolar ANA
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Scleroderma, polymyositis, vasculitis
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Anti-dsDNA
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SLE (exacerbation, active state, dec'd with therapy)
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Anti-Sm
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SLE (does not correlate well with disease activity)
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Anti-cardiolipin
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SLE
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Anti-SSA (Ro)
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SLE & Sjogren's
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Anti-SSB (La)
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SLE & Sjogren's
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Antihistone
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Drug-induced lupus
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Anti-Scl70
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Scleroderma
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RF
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RA (but not specific), severity of disease & presence of nodules
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Anti-CCP
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RA (much sooner & more accurate - more likely to develop erosive type)
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ANCA
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Wegner's granulomatosus
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C3
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Most abundant, 1st measured
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C4
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More sensitive & specific
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CH50
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Total complement
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Acute phase reactants
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CRP, fibrinogen, ferritin, complement
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hs-CRP
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CV disease
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Anti-thyroglobulin
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thyroid
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Anti-peroxidase
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thyroid
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Anti-microsomal
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thyroid
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ASMA
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Liver & bile duct AI disease, hepatitis, biliary cirrhosis, asthma
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APCA
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Pernicious anemia & chronic gastric disease
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ASO
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Dx of prior not acute infxn, inc'd in RF, glomerulonephritis, pyoderma
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RPR
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2 and latent stages of syphilis, non-Treponemal, screening test
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FTA-ABS
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Confirms dx of syphilis, Treponemal
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VDRL
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Tertiary syphilis (neurosyphilis)
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Lyme
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Elisa (screen), Western Blot (confirm)
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Calcitonin
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Thyroid medullary carcinoma, oat cell, breast, pancreatic
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CEA
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Colorectal cancer but not reliable or specific
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AFP
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Testicular CA, hepatic CA, hepatomas, neural tube defects, ovarian cancer
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B-HCG
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Pregnancy, trophoblastic tumors, hydatidform moles, breast & testicular CA
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PSA
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BPH & prostate CA
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CA-125
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Ovarian CA
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CA 15-3, CA 27.29
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Breast cancer staging and monitoring tx
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CA19-9
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Pancreatic & hepatobiliary, stomach CA
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EBV
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Burkitt's lymphoma, nasopharyngeal CA
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HBV
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Hepatocellular CA
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HHV8
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Kaposi's sacroma
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HPV
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Cervical carcinoma
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HTLV1
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Adult T-cell leukemia
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