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62 Cards in this Set

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What is the definition of labor?
regular contractions causing cervical dilation (4cm) and effacement
DDX of labor.
- Braxton-Hicks contractions: contraction without dilation
- normal dilation
- cervical incompetency: dilation without contraction
What is this called?

- patient reports change in abd shape(lower portion more prominent), sensation of baby gotten less heavy/dropping, frequent urination
lightening
- normal event of late pregnancy
What are some indications for pregnancy women to come to the hospital?
- contraction every 5min for at least 1 hr
- sudden gush of fluid ot constant vaginal leakage of fluid
- vaginal bleeding
- significant decrease in fetal movement
Components of a limited general physical exam of a pregnant women.
- vital signs
- abdominal (Leopold maneuvers), pelvic exam
- auscultation of fetal heart tones
- transabdominal u/s
What can be determined by doing a leopold maneuver?
- lie: relation of long axis of the fetus with the maternal long axis (longitudinal, transverse, oblique)
- presentation: breech, cephalic
- position: relation of the fetal presenting part to the left or right side of the maternal pelvis. LOA is the most common.
Components of the leopold maneuvers.
1. determinw what occupies the fundus
2. determine location of small parts
3. identify descent of the presenting part
4. identify the cephalic prominence
Sequence of a vaginal exam.
- speculum exam always precedes digital exam
- delay digital exam if membrane is ruptured
What are the 5 parts of the cervical exam?
1. dilation
2. effacement: 4cm is uneffaced
3. station: -5 to +5, or -3 to +3. relative level of the foremost part of fetal presenting part to the level of the ischial spines
4. consistency: softness
5. position
What is the station is the fetus is said to be engaged?
0 station
- greatest transverse diameter of the fetal skull is negotiated the pelvic inlet
Stages of labor.
Stage I: onset of labor to full cervical dilation
- latent phase: cervical effacement and dilation
- active phase: more rapid cervical dilation beginning at 4cm

Stage II: complete dilation to delivery

Stage III: delivery of infant to delivery of placenta

Stage IV: 2 hrs postpartum after delivery of placenta
What are the cardinal movements of labor?
- engagement: days-wks before labor for primigravidas, onset of labor for multigravidas
- flexion
- descent: greatest descent during the latter portion of 1st stage and 2nd stage
- internal rotation
- extension
- external rotation
What are the 3 Ps of labor mechanics?
- passage: adequacy of pelvis
- passenger
- power: force of contraction (montevideo), avg 180-250 MVU
How fast shoud the cervix chage during the 1st stage of labor?

- nullioparas
- multiparas
- nullioparas: 1.2cm/hr
- multiparas: 1.5cm/hr
How long is too long for stage II labor?

- nullioparas
- multiparas
- nullioparas: 2 hrs
- multiparas: 1 hr
What can you do to ripen the cervix?
- foley bulb
- oxytocin IV
- cytotec
- cervidil
- laminaria
- membrane stripping (digital)
- amniotomy
What is the most common cause of perinatal morbidity and mortality?
preterm birth
Complications of preterm birth.
- perinatal death
- respiratory distress
- intraventricular hemorrhage
- necrotizing enterocolitis
- sepsis
- neurologic impairment
- seizures
What are some long term morbidity associated with preterm deliveries?
- bronchopulmonary dysplasia
- developmental abnormalities: cerebral palsy
What is the definition of preterm labor?
- regular uterine contractions q10min or less between 20-36 wks of gestation with each contraction lasting at least 30s
- accompanied cervical effacement, cervical dilation, and/or descent of the fetus into the pelvis
What are some factors associated with preterm labor?
- african american race
- prior hx of preterm birth
- preterm uterine contraction
- incomoetent cervix
- infections
- multiple gestations
- placental abnormalities: abruption, previa
- excessive uterine enlargement
- uterine distortion
What are some preventative measure for preterm labor?
1. transport to tertiary center if no NICU at site
2. corticosteroid for fetal lung maturity
3. stop pitocin to prolong pregnancy
4. GBS prophylaxis
What are some signs and symptoms of preterm labor?
- menstrual like cramps
- low, dull backache
- abdominal and pelvic pressure
- increase/change in vaginal discharge
- uterine contractions
-
What does this indicate?

- absence of fetal fibronectin in maternal vaginal secretions
patient likely to deliver in 7 days after sample is taken
Is home uterineactivity monior recommended for preterm labor management?
Not anymore.
It is effective in the recognition fo PTL but no difference in outcome.
Should you treat pregnant women with bacterial vaginosis who is asymptomatic?
NO. treatment is not beneficial in decreasing the occurrence of PTL.

Treat if patient is symptomatic.
How to diagnose bacterial vaginosis? (hint, criterias)
3 or 4 of the following
- homogenous vaginal discharge
- clue cells on saline microscopy
- fishy odor with KOH to vaginal secretions
- vaginal pH > 4.5
What is a reliable method to assess cervical length?
transvaginal u/s
Would cervical cerclage helpful in this case?

- decreased cervical length < 2.5cm
not helpful to as a prophylactic treatment for preterm labor
What has been shown to be beneficial in decreasing cases of PTL?
weekly IM injections of progesterone, 17-a-hydroxyprogesterone caproate.
What to do next for this patient?

- 30 wk gestation
- menstrual like cramps
- low, dull backache
- painless uterine contractions
You should suspect preterm labor

Next
- external fetal monitor
- status of cervix by speculum exam
- UA and urine culture to r/o infection (GC and chlamydia) because infection could be the cause of preterm labor
- empirical treatment for GBS till culture result is back
- u/s to assess gestational age, amniotic fluid volume
- amniocentesis: infection if white cells present
What should you do next?

- amniocentesis confirmed intrauterine infection
delivery regarless of gestational age
Management for preterm labor.
- IV hydration
- tocolysis: MgSO4 (6g in 100-150cc D5W loading dose and then 2g/hr infusion), or terbutaline/ritodrine, or indomethacin, or nifedipine (30g loading dose, 20mg q6-8hrs)
- steriods to enhance pulmonary maturity
T/F: One might be more willing to accept potential adverse effects for patients in PTL at 26 wks than 33 wks.
True
T/F: It is customary not to initiate or stop therapy for preterm labor after 35-36 wks.
True
What are some contraindications to tocolysis?
- advanced labor
- mature fetus
- severely anomalous fetus
- intrauterine infections
- significant vaginal bleeding
Mechanism and side effects of magnesium sulfate.
Mechanism: competes with Ca for entry into cells

Side effects:
- flushing, headaches
- respiratory/cardiac depression at high doses
Mechanism and side effects of terbutaline.
Mechanism:
- beta adrenergic: increases cAMP in cell which decreases free Ca

Side effects
- hypotension, tachycardia
- ECG changes
- anxiety
- increased pulmonary edema
Mechanism and side effects of indomethecin.
Mechanism
- decrease prostaglandin production by blocking conversion of arachidonic acid to PG

Side effects:
- premature constriction of ductus arteriosus
- reversible impaired fetal renal function and oligohydramnios with prolonged exposure
Mechanism and side effects of nifedipine (ca channel blocker).
Mechanism
- prevent Ca entry intto muscle cells

Side effects
- decrease in uteroplacental blood flow
- fetal hypoxia
- hypercarbia
Definition of abortion.
loss (termination or end) of a pregnancy before viability (20wks from LMP or a fetus weighing < 500g.
What is the incidence of spontaneous abortion?
50% of all pregnancy (many are clinicallty unrecognized)
- 15-25% sited
- 80% losses occur during first 12wks.
Approximately 50% of early spontaneous abortions are attributed to chromosomal abnormalities. What is the most common chromosomal defect?
- trisomies (40-50%): 21, 13, 18
- monosomy X (15-25%)
- triploidy (15%)
- tetraploidy (5%)
Risk factors associated with spontaneous abortion?
- increasing parity
- increasing maternal age
- increasing paternal age
- conception within 3 months of a live birth
What is the clinical significance of separating first trimester miscarriages and second trimester miscarriages?
Conidtions associated with later miscarriages can often be treated: maternal systemic diseases, abnormal placentation or anatomic abnormalities.
What are some maternal factors that are associated with spontaneous abortions?
1. infections
- listeria monocytogenes
- mycoplasma hominis
- ureaplasma urealyticum
- toxoplasmosis
- viral: rubella, CMV

2. systemic diseases
- luteal phase inadequacy: insufficient secretion of progesterone by corpus luteum or the placenta
- hypothyroidism
- SLE
- DM

3. environmental factors
- smoking, heavy caffeine intake, alcohol

4. uterine factors
- submucous leiomyomata uteri: need myometry
- unicornuate or septate uterus
- exposure to DES
- intrauterine synechiae (Asherman syndrome): inadequate endometrium to support implanation
What is the treatment for luteal phase inadequacy?
- clomiphene: stimulate FSH and hCG
How is luteal phase defect diagnosed?
appropriately timed endometrial biopsy
What are some paternal factors associated with spontaneous abortion?
chromosomal abnormailties
What are some fetal factors associated with spontaneous abortion?
- genetic abnormalities
T/F: any vaginal bleeding in the first half of an intrauterine pregnancy is presumptively called a threatened abortion.
True
What is threatened abortion?
bleeding in the first trimester without losses of fluid or tissue
Complications of threatened abortion which is viable.
- pretern delivery
- low birth weight
- perinatal mortality

*no risk of malformations
What type of abortion is this?

- cervix closed
- vaginal bleeding
threatened abortion
- no intervention necessary
- measures to controll bleeding if bleeding persists
How to identify viable pregnancies at various stages of pregnancy?
ultrasound + quantitative hCG
What type of abortion is this?

- ROM and/or cervical dilation during first half of pregnancy
- pregnancy loss is unavoidable
inevitable abortion
- typically followed by uterine contraction and expulsion of products of conception
What type of abortion is this?

- spontaneopus passage of all of the products of conception
complete abortion
What type of abortion is this?

- partial expulsion of pregnancy tissue
- bleeding and pain
incomplete abortion
- need suction curettage or prostaglandins to remove remaining tissue and prevent further bleeding and infection
- postevacuation treatment with ergot derivative (methergine) and abx (doxycycline)
What type of abortion is this?

- retention of failed intrauterine pregnancy for more than 2 menstrual cycles
missed abortion
- absence of uterine growth
- loss of early symptoms of pregnancy
Management for missed abortion.
evacuation of the uterus
- suction curettage for pregnancy in the first trimester
- D&C or prostaglandins for pregnancies that have advanced to second trimester
What are some maternal causes of recurrent late abortions?
- incompetent cervix
- uterine abnormalities: septate uterus
- intrauterine synechiae (Asherman syndrome): treated with lysis of synechiae and postop estrogen to reestablisn endometrial layer
What is the diagnosis?

- cramping pain and bleeding
- open cervix
- large "softer than expected" uterus
Postabortal syndrome
- presentation indistinguishable from incomplete abortion
- path report of curettage tissue
- treated with oxytotic and abx (same as in incomplete abortion)