Cleaver Biochem Derm Lecture

Front 1

List 3 Types Non-Pigment Lesions?

Back 1

1. Actinic Keratosis
2. Basal Cell
Squamous Cell Carcinoma of Skin

Front 2

Actinic Keratosis Description:

_____ patches often on an _____ - some w/ _______

Back 2

Hyperkeratotic Patches
Often on an Erythematous Base
-some w/ Telangiectasias

Front 3

Actinic Keratosis:
Occurs In ____

Back 3

Sun-exposed Areas

Front 4

Actinic Keratosis:
Describe Surface Texture?

Back 4

Very rough surface texture

Front 5

Actinic Keratosis:
If left untreated, may develop into what 2 things?

Back 5

Basal Cell Carcinoma
Squamous Cell Carcinoma

Front 6

Actinic Keratosis:
4 Txs?

Back 6

1. Prevention s/ sun screen & clothing

2. Topical 5-FU

3. Cryosurgery

4. Close-follow up

Front 7

Basal Cell:
How Common?

Back 7

Most Common Cancer

Front 8

Basal Cell:
5 Causes?

Back 8

1. Sun
2. Radiotherapy for acne
3. Arsenic
4. Xeroderma pigmentosum
5. basal cell nevus syndrome

Front 9

Basal Cell:
More common in what 2 types ppl?

Back 9

1. Fair Skin
2. > 50 yrs old

Front 10

Basal Cell:
3 Characteristics?

Back 10

1. Pearly Papules
2. Pearly Nodules
3. Ulcerations

Front 11

Basal Cell:
Do they metastasize?

Back 11

Rarely

Front 12

Basal Cell:
Do they invade deeper structures?

Back 12

Yes

Front 13

Basal Cell:
6 txs?

Same txs for what else?

Back 13

1. Removal:
a. surgery
b. Cryosurgery
c. shave w/ electrodesiccation & curettage

2. Moh's
3. Avoid Sun
4. check-ups


squamous cell carcinoma of skin

Front 14

Basal Cell:
When would you esp use moh's to tx?

Back 14

If recurrent

Front 15

Squamous Cell Carcinoma of Skin:

1. Where found and on whom?

Back 15

1. Sun Exposed Areas
2. Elderly

Front 16

Squamous Cell Carcinoma of Skin:
2 Clinical Features?

Back 16

Ulcerated tumors

Hyperkeratotic Tumors

Front 17

Squamous Cell Carcinoma of Skin:

4 risk factors?

Back 17

sunlight

radiation

Arsenic

Chemo

Front 18

Squamous Cell Carcinoma of Skin:

Metastatic?

Back 18

Rarely, but > than basal cell

Front 19

Squamous Cell Carcinoma of Skin:

2 places Where usually found?

Back 19

Lip

Ear

Front 20

Squamous Cell Carcinoma of Skin:

Although rarely metastatic, mroe metastatic than what?

Back 20

Basal Cell Carcinoma

Front 21

Squamous Cell Carcinoma of Skin:

Tx?

Back 21

Same As basal Cell

Front 22

2 General Types Pigment Lesions?

Back 22

1. Premalig Lesions

2. Malignant Lesions

Front 23

What 3 things are VERY impt to remember concerning pigment lesiosn?

Back 23

1. early detection is impt

2. varying clinical presentation

3. High Incidence

Front 24

3 Types Pre-malig lesions?

Back 24

1. Lentigo Maligna

2. Congenital Melanocytic Nevi

3. Dysplastic Nevi (AMN)

Front 25

Lentigo Maligna:

1. Describe growth?

2. % that will become malignant?

3. Avg age of those w/ malignant type?

Back 25

1. Slow, radial growth

2. 30%

3. 70

Front 26

Lentigo Maligna:

1. How to dx?

Back 26

Biopsy darkest portion
or
biopsy palpable portion

Front 27

Lentigo Maligna:

1.3 Tx?

Back 27

1. No therapy

2. Superficial Removal (5-FU, dermabrasion, cryotherapy)

3. Surgical removal

Front 28

Congenital Melanocytic Nevi:

1. How common?

Back 28

1% newborns

Front 29

Congenital Melanocytic Nevi:

Size of lesion in < 1 of 20,000 births?

Back 29

> 10 cm

Front 30

2 Types Congenital Melanocytic Nevi?

Back 30

1. Giant Congenital Melanocytic Nevi

2. Small Congenital Melanocytic Nevi

Front 31

Giant Congenital Melanocytic Nevi:

1. 3 Diff appearances?

Back 31

1. Coat Sleeve

2. Bathing trunk Nevi

3. Dermatome

Front 32

Giant Congenital Melanocytic Nevi:

1. Those w/ Giant Congenital Melanocytic Nevi have a 6.3% risk of developing what early in childhood?

Back 32

melanoma

Front 33

Giant Congenital Melanocytic Nevi:

1. Tx?

Back 33

1. Prophylactic Full thickness removal

Front 34

Small Congenital Melanocytic Nevi:

size?

Back 34

3-4 cm

Front 35

Small Congenital Melanocytic Nevi:

When present?

Back 35

Birth

Front 36

Small Congenital Melanocytic Nevi:

Risk?

Back 36

1 in 20 -to- 1 in 38 if pt lives to 60 yrs old

Front 37

Small Congenital Melanocytic Nevi:

Tx?

Back 37

Prophylactic Excision

Front 38

Dysplastic Nevi (AMN):

Incidence?

Back 38

75% - 80% Whties have:
nevo-cellular nevi

1-2% whites have dysplastic nevi

Front 40

Dysplastic Nevi (AMN):

It is a Risk Factor for?

Back 40

sporadic melanoma

Front 41

Dysplastic Nevi (AMN):

1 risk factor for AMN?

Back 41

familial melanoma (2 or > blood relatives)

Front 42

Suspect Dysplastic Nevi (AMN) if you see:

1. Varied Color of _____

2. Border is ____, ____, ____

3. Size is _____

4. Surface texture is ______

5. Lesion is______

Back 42

1. Black, Brown, red, blue, white

2. Irregular, Angular, Notched

3. Increasing

4. Irregular

5. Symptomatic

Front 43

Dysplastic Nevi (AMN):

What is BK-Mole Syndrome?

Back 43

Multiple AMNs

Front 44

Dysplastic Nevi (AMN):

Tx?

Back 44

1. Early Recognition
2. Surgical removal
3. Histological Exam

Front 45

4 types malignant lesions?

Back 45

1. Superficial Spreading Melanoma

2. Lentigo Maligna Melanoma

3. Acral-Lentiginous Melanoma

4. Nodular Melanoma

Front 46

Superficial Spreading Melanoma:
1. Usually Occurs what age?

Back 46

Mid life

Front 47

Superficial Spreading Melanoma:

Where and on whom does it occur?

Back 47

1. backs of men

2. legs of women

Front 48

Superficial Spreading Melanoma:
May develop _______

Back 48

nodular lesions

Front 49

Lentigo Maligna Melanoma:

Develops in _____

Back 49

Lentigo Maligna

Front 50

Lentigo Maligna Melanoma:

Size?

Back 50

6-7 cm

Front 51

Lentigo Maligna Melanoma:
May develop in small ____ areas of ____ damaged elderly adults

Back 51

1. sun exposed areas

2. actinically damaged

Front 52

Acral-Lentiginous Melanoma:
1. Where?

Back 52

palm, soles, nail bed, mucous membrane

Front 53

Acral-Lentiginous Melanoma:

What Ppl groups get it?

Back 53

1. blacks
2. orientals

Front 54

Acral-Lentiginous Melanoma:
2 types growth phases?

Back 54

1. horizontal growth phases - flat or pigmented

2. vertical growth phases

Front 55

Nodular Melaoma:

May develop in _____.

Back 55

Superficial Spreading Melanoma

Front 56

Nodular Melaoma:

Begins as what color?

Progresses to what colors?

Back 56

1. blue-black

2. purple, red-brown, amelanotic (white;albino)

Front 57

Nodular Melaoma:

Often mistaken for what 2 things?

Back 57

blood blister

hemangioma

Front 58

Nodular Melaoma:

Tx?

Back 58

surgery by experienced melanoma surgeon