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7 Cards in this Set
- Front
- Back
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Primary biliary cirrhosis
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Autoimmune disorder-granulomatous destruction of bile ducts in portal triads
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PBC age group
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40-50
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Pathogenesis of PBC
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progress from chronic inflammatory reaction to cirrhosis
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Clinical findings PBC
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pruritis-deposit bile salts in skin-BEFORE jaundice
Hepatomegaly Jaundice-LATE finding, after most bilde ducts have been destroyed Portal HPT Increased risk for hepatocellular carcinoma |
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Lab findings PBC
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Antimitochonedrial antibodies
Increased IgM |
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Secondary biliary cirrhosis
SBC |
Complication of chronic extrahepatic bile duct obstruction-
Example is CF-bile is dehydrated NO INCREASE in antimitochondrial AB's or IgM |
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Secondary causes of hemochromatosis
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multiple blood transfusions
(ex. sickle cell, anemia, thalassemia major) OH abuse(OH inc. iron absorption) |
