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17 Cards in this Set
- Front
- Back
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What are the vessels and purpose of portal triad?
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•Hepatic Artery: carries oxygenated blood to the liver
•Portal Vein: carries blood to the liver for processing •Bile duct: transporting bile into GI or gall bladder |
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What is the venous return from the liver to the heart?
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1. Central vein
2. Hepatic vein 3. Inferior vena cava 4. Heart |
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What are the cells?
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Hepatocytes
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How are the cells arranged in the liver?
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•Hexagonal
•Thin, single, layers of hepatocytes Portal triads at the corners •Highways aka sinusoids |
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What is the blood flow direction in the liver?
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•Portal triad towards central vein
oHepatic artery: into the liver oPortal vein: into the liver oBile duct: out of liver |
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Is the liver a low or high hydrostatic pressure system?
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•Low hydrostatic pressure system
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Where is cirrhosis in the spectrum of liver disease?
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End-stage
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Which characteristics would describe cirrhosis?
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•Diffuse
•Irreversible •Chronic •Severe |
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What is a common use for the Child-Pugh grading system?
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•Dosing in hepatic impairment
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What is a disadvantage of Child-Pugh?
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2 subjective components:
o Ascites o Encephalopathy |
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Does age affect the MELD score?
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•NO
•Designed for adults >12 yo |
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What are the factors that influence MELD?
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•SCr (and on hemodialysis)
•Bilirubin •INR |
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What are the 4 normal liver functions?
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•Energy Metabolism and Substrate Conversion
•Protein Synthesis •Solubilization, transport, and storage •Protection and Clearance |
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Why is energy metabolism and substrate significant?
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Conversion of ammonia to urea (Hepatic Encephalopathy)
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Why is protein synthesis significant?
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Albumin (Ascites)
Clotting factors (Coagulopathy, esophageal varices, elevated INR) |
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Why is solubilization, transport, and storage important?
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Solubilization of fat and fat-soluble vitamins (bile functions)
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Why is protection and clearance significant?
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Detoxification of ammonia via the urea cycle.
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