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5 Cards in this Set
- Front
- Back
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Name 4 pathogens that can cause chronic granulomatous lung disease
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Tuberculosis
Histoplasmosis Coccidiomycosis Blastomycosis |
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What leads to a predisposition to tuberculosis and impaired granuloma formation in humans?
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IFN-γ receptor deficiency
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What receptor deficiency in humans leads to severe tuberculosis?
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IL-12 receptor
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What is the mechanism of cytokine interaction in pulmonary TBC infection?
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Inhaled TBC invades pulmonary dendritic cells, which secretes IL-12 and presents antigens to T cells and macrophages
Th1 response leads to IFN-γ activation of macrophages IFN-γ activates NOS CTLs kill TBC infected macrophages and form caseous granulomas |
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What enzymes is necessary to control TBC infections?
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NOS
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