Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
22 Cards in this Set
- Front
- Back
|
Chronic Leukemias
|
- increase of mature leukocytes in peripheral blood
- >90% represent clonal overgrowht of B-type cells and accumulation of malignant lymphocytes |
|
|
Chronic Lymphocytic Leukemia (CLL)
|
- uncommon before 50
- median age 68 - 2x more in males - survival 2 to 10 years - cause of death is infection due to altered humoral immunity (hypogammaglobulinemia), about 1/3 develop autoimmune hemolytic anemia |
|
|
Stages of CLL
|
- a disease of progressive accumulation of nonfunctioning lymphocytes
- stages reflect accumulation |
|
|
Stage 0 CLL
|
- bone marrow and blood lymphocytosis
- survival 150 months |
|
|
Stage 1 CLL
|
- lymphocytosis with enlarged nodes
- survival 101 months |
|
|
Stage 2 CLL
|
- lymphocytosis with enlarged spleen and/or liver
- survival 71 months |
|
|
Stage 3 CLL
|
- lymphocytosis with anemia
- survival 19 months |
|
|
Stage 4 CLL
|
- lymphocytosis with thrombocytopenia
- survival 19 months |
|
|
Signs and Symptoms of CLL
|
- insidious, slow onset
- malaise, low-grade fever, night sweats, weakness, fatigue, anorexia, and weight loss - cervical and supraclavicular adenopathy and hepatosplenomegaly |
|
|
CLL Lab Data
|
- WBC 30-200x10^9/L
- absolute lymphocytosis - 80-90% small lymphs - some lymphoblast, smudge cells - B cells display surface immunoglobulin (SIg) marker * B cells can be ID by monoclonal antibodies as expressing CD19, CD20, Cd24 and CD5 markers |
|
|
Multiple Myeloma
|
- increase number of plasma cells in the blood
- age 40-70 onset - 2x more in blacks than whites - decrease normal antibodies |
|
|
MM Lab Data
|
- anemia
- rouleaux formation - Bence Jones protein in urine - bleeding |
|
|
The most common form of chronic leukemia is:
A.) myelogenous B.) lymphocytic C.) monocytic D.) eosinophilic |
B.) lymphocytic
|
|
|
The median survival time of patients with CLL, compared with patients with chronic monocytic leukemia, is:
A.) not significantly different B.) shorter C.) longer D.) shorter, if the patient is female |
C.) longer
|
|
|
CLL is classically a:
A.) T cell disorder B.) B cell disorder C.) null cell disorder D.) disorder of the young |
B.) B cell disorder
|
|
|
CLL symptoms frequently include:
A.) weight loss, anemia, and extreme leukocytosis B.) absolute lymphocytosis, edema, and splenic infarction C.) absolute lymphocytosis, malaise, and low-grade fever D.) neutrophilia, splenomegaly, and anemia |
C.) absolute lymphocytosis, malaise, and low-grade fever
|
|
|
Characteristics of malignant lymphoma typically include:
A.) overproliferation of neutrophils B.) overproliferation of lymphocytes C.) lymph node involvement D.) both B and C |
D.) both B and C
|
|
|
Hodgkin's disease:
A.) is characterized by neutrophilia in the early stages of the disease B.) occurs more frequently in females than males C.) is a lymphoma, characterized by Reed-Sternberg cells, and occurs more frequently in females than in males D.) is a lymphoma, characterized by Reed-Sternberg cells, and occurs more frequently in males than in females |
D.) is a lymphoma, characterized by Reed-Sternberg cells, and occurs more frequently in males than in females
|
|
|
Rare forms of lymphoma include:
A.) Hodgkin's and non-Hodgkin's lymphoma B.) Burkitt's lymphoma and mycosis fungoides C.) Hodgkin's and non-Hodgkin's lymphoma and Burkitt's lymphoma D.) Non-Hodgkin's lymphoma and mycosis fungoides |
B.) Burkitt's lymphoma and mycosis fungoides
|
|
|
Multiple myeloma is a disorder of:
A.) T lymphocytes B.) megakaryocytes C.) plasma cells D.) the lymph nodes |
C.) plasma cells
|
|
|
The abnormal protein frequently found in the urine of persons with multiple myeloma is:
A.) albumin B.) globulin C.) IgG D.) Bence Jones |
D.) Bence Jones
|
|
|
Waldenstrom's macroglobulinemia is characterized by increased levels of:
A.) IgG B.) IgM C.) IgD D.) IgA |
B.) IgM
|
