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52 Cards in this Set
- Front
- Back
|
Rb
|
13q (like BRCA2)
retinoblastoma, osteosarcoma |
|
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brca1
|
17q (like NF1)
breast and ovarian |
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brca2
|
13q (like Rb)
breast |
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p53
|
17p
most human cancers, li-fraumeni syndrome |
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p16
|
9p
melanoma |
|
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APC
|
5q (like criduchat)
colorectal cancer associated with Familial Adenomatous Polyposis |
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WT1
|
11p
wilms tumor |
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NF1
|
17q (like BRCA1)
neurofibromatosis 1 |
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NF2
|
22q
neurofibromatosis 2 |
|
|
DPC and DCC
|
18q
pancreatic/colon cancer |
|
|
Rb
|
13q (like BRCA2)
--> retinoblastoma, osteosarcoma |
|
|
brca1
|
17q (like NF1)
--> breast and ovarian |
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|
brca2
|
13q (like Rb)
--> breast |
|
|
p53
|
17p
--> most human cancers, li-fraumeni syndrome |
|
|
p16
|
9p
--> melanoma |
|
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APC
|
5q (like criduchat)
--> colorectal cancer associated with Familial Adenomatous Polyposis |
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|
WT1
|
11p
--> wilms tumor |
|
|
NF1
|
17q (like BRCA1)
--> neurofibromatosis 1 |
|
|
NF2
|
22q
--> neurofibromatosis 2 |
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|
DPC and DCC
|
18q
--> pancreatic/colon cancer |
|
|
abl
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CML
|
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c-myc
|
burkitt lymphoma
|
|
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bcl2
|
follicular and undiff lymphomas (inhibits apop)
|
|
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erb-B2
|
breast ovaria and gastric carcinoma
|
|
|
ras
|
colon carcinoma
|
|
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l-myc
|
lung
|
|
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n-myc
|
neuroblastoma
|
|
|
ret
|
MEN 2 and 3
|
|
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c-kit
|
gastrointestinal stromal tumor (GIST)
|
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aflatoxin
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HCC
|
|
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vinyl chloride
|
liver angiosarcoma
|
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ccl4
|
liver centrilobular necrosis and fatty change
|
|
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nitrosamines (smoked foods)
|
esoph and stomach ca.
|
|
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cigarettes
|
laryngeal sqcc
lung sqcc or smcc kidney rcc bladder tcc |
|
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asbestos
|
mesothelioma and bronchogenic carcinoma
|
|
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arsenic
|
skin sqcc
liver angiosarcoma |
|
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naphthalene (aniline dyes)
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bladder tcc
|
|
|
alkylating agents
|
blood leukemias
|
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ACTH/ACTH-like peptide
|
small cell carcinoma of lung
cushings |
|
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ADH
|
small c. Ca.
intracranial neoplasms siadh |
|
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PTH, TGFb TNF IL1
|
sqcc lung, rcc, breast ca
hypercalcemia |
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erythropoeitin
|
RCC, hemangioblastoma
polycythemia |
|
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Ca++ channel antibodies
|
thymoma, small c ca. lung
lambert eaton |
|
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hyperuricemia
|
leukemia/lymphoma (cytotoxic therapy)
gout and urate nephropoathy |
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|
prostate cancer morb/mort
|
32 morbidity
13 mortality |
|
|
male lung cancer morb./mort
|
16 morbid
33 mortality |
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female lung cancer morb mort
|
13 morbid
23 mort |
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breast cancer morb/mort
|
32 morbid
18 mort |
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female/male colon cancer morb
|
about 13/12 respectively
|
|
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mets to bone
|
PT Barnum loves kids
prostate thyroid/testes breast lung kidneys LYtic - Lung and thYroid blastic - prostate BOth - BOobs |
|
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mets to liver
|
cancer sometimes penetrates benign livers
colon > stomach> pancrease > breast . lung note colon stomach and pancreas are all part of the GI which has easy access to liver. |
|
|
mets to brain
|
lots of bad stuff kills glia
lung breast skin (melanoma) Kidney GI cancers |
