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6 Cards in this Set
- Front
- Back
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CML accounts for
Caused by translocation This creates a This activates |
20% adult leukaemias
9(abl):22(bcr) const. active tyrosine kinase Ras, P13K, Jak-STAT, Jun, NF-kB |
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The fusion of Bcr-Abl means the loss
What did this contain v-able also what do this mean for v-abl What domain does Gleevec bind to? What % patients cured? The rest must of... What drug can overcome resistance? This binds to? |
of N-terminal Abl region
SH3 domain for interacting with proline-rich domains has lost n-terminal region can't autoinhibit - replicates faster ATP-binding site in the calaytic cleft 90% Acquired mutation at T315I PKC412 PDGFRalpha |
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Follicular B cell Lymphoma is caused by?
What chromosomal translation? What does Bcl-2 do? Bcl-2 alone can't cause cancer... Treat with? |
Bcl-2 activation
Bcl-2 transl. downstream of an Ig promoter tr(14:18) Blocks pore in mitochrondria preventing depolarisation and release of cytochrome C from the inner and outer mito membranes Needs c-myc Rutixmab an anti-CD20 B cell rec |
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EBV transforms
Cells in Burkitt's are immortal but still Translocation is What is on chr.8? Initially cells become sensitive to apoptosis because? Then cancerous because? This mimics and activates and overrides? Overtime the cells can become less dependent on LMP2A because? Burkitt's occurs mainly Vaccines against EBV would prevent this as? |
resting B cell into proliferating blast - 10-100% of the time
have diploid karyotype 8:14 c-myc c-myc induces P14ARF which inhibits MDM2 and activates p53 Mutation in LMP2A Mimics RTKs and activates P13K, Ras, NF-kB and overrides p53 p53 mutation has occured Sub-saharan Africa 100% children with Burkitt's have high viral genome load |
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AML-1 is a
Most common translocations As well inversion on KO mice AML-1 binds to DNA via Also forms heterodimer with Induces haematopoeitic genes: |
TF
8:21, 16:21, 3:21 chr. 16 have no blood runt domain CBF-Beta GM-CSF, IL-2 and TCF |
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Other AML-1 translocation include (5)
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AML1/ETO (8:21) -truncated protein blocks AML1 function, recruits HDACs and CBF-beta can't bind
MOX-CBP (8:21) 4/1000 const. act HATs MLL-CBP >80% infant leuk CBF-Beta -smooth muscle MHC: sequesters CBF-Beta to cytoplasm RAR-PML (15:17) |
