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35 Cards in this Set
- Front
- Back
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M1 Receptors
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Brain
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M2 Receptors
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Heart
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M3 Receptors
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Glands and endothelium
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Nn receptors
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Post Ganglionic cell body, Dendrites
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Nm receptors
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Skeletal muscle (Neuromuscular Junction)
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Eyes and Open Angle Glaucoma treatment
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Pilocarpine
Charbachol ACHEI |
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Pilocarpine
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(Muscarinic Partial Agonist)
Cholinergic drug of choice Increase US outflow (ativation of receptors of iris and cilliary body smooth muscle) |
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Charbachol (CCh)
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Substitute for Pilocarpine in Open Angle Glaucoma
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ACHEI
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Can be used in open angle glaucoma
Could Cause Cataracts or retinal detachment |
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Adverse effects of ACHEI
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Increase tension in peripheral retina
Induces myopia (increased lens curvature) Pupillary block Decrease night visión Increased axial opacities |
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Treatment for: Reflux, Esphagitis, Ileus, Megacolon
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Betanechol
Edrophonium (ACHEI) Neostigmine (ACHEI) |
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Treatment for: Urinary Retention
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Betanechol
Neostigmine |
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Treatment for: Xerostamia
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Pilocarmine
Cevimeline M1 and M3 Effect |
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Diagnosis between cholinergic vs Myasthenic Crisis
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Edrophonium Test (Short acting reversible inhibitor)
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Maintinance of Myasthenia gravis
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Neostigmine, pyridostigmine (Carbamate-class AchE inhibitors)
Ambemonium (long-acting) |
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Myasthenia drugs SE:
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SE: abdominal cramps, blurred vision, hypersecretion, miosis, bradycardia, mental confusion.
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Dementia
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Tacrine
Donepezil, Rivastigmine: AChEI. Galantamine: AChEI + stimulates Ach release. Memantine: NMDA antagonist, blocks toxic effect associated w/ excess glutamate and regulates glutamate activation. |
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Tacrine
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ACHEI, Removed from Market due to Hepatotoxicity
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Arrythmias, supraventricular and paroxismal SV tachycardia
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Edrophonium
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Detox from atropine, belladona alkaloids, TCA
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Physostigmine
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Skeletal muscle relaxant
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Succinylcholine
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Reversal of nondepolarizing blockade (Curare)
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Neostigmine
Pyridostigmine |
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Muscarinic Agonist toxicity
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Diarrhea
Urination Miosis Bronchospasm Bradycardia Excitation of skeletal muscle and CNS Lacrimation Sweating Salivation TREATMENT: ATROPINE |
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Atropine
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Blocks Muscarinic Effects
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Nicotinic Agonist Toxicity
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Acute
CNS stimulation Convulsions Respiratory collapse Hypertension Chronic Coronary disease Cancer Peptic ulcer Treatment: Anticonvulsants |
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ACHEI Toxicity Tratment
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Atropine And Oxime
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Oxime
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Binds to site of inhibition, displaces organophosphates and rescues enzyme.
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Muscarinic Antagonist used for: Eyes
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tropicamide
Atropine |
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Muscarinic Antagonist used for: Parkinson’s
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Benztropine
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Muscarinic Antagonist used for: Peptic Ulcer, Hypermotility, antidiarrheals
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3ry amines
Pirenzepine Dicyclomine Scopolamine Atropine Glycopyrroalate 4ary amines Propantheline Glycopyrrolate |
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Muscarinic Antagonist used for: Urinary Incontinence, Bladder Inflamation
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Atropine
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Muscarinic Antagonist used for: Bronchitis, Athma, COPD
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3ry amines
Atropine 4ry Amines Ipratropium (+/-) Albuterol Tiotropium |
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Emesis Agonists
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Tacrine, ACHEI, Betanechol
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Emesis Antagonist
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Scopolamine
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Scopolamine
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Used for post operative antiemesis
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