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46 Cards in this Set
- Front
- Back
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Acetylcholine
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What is it?
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Bethanechol
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what is it?
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Carbachol
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what is it?
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Edrophonium
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What is it?
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Methacholine
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Resistant to AChE
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Pilocarpine
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M3 Agonist
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Ganglionic Blockers
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MeTH
Mecamylamine Trimethaphan Hexamethonium |
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Muscarinic Blockade
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Blind as a bat
Hot as hell Red as a beet Dry as a bone Mad as a hatter |
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Scopolamine
Route? Tx? Contrainidications? |
Muscarinic Blocker
Oral/Opth/Transdermal Tx for motion sickness Contraindicated in Glaucoma |
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Anticholinergics (8)
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PISS BOAT
Pancuronium Ipratropium Succinylcholine Scopolamine Benztropine Oxybutinin Atropine Tropicamide |
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M 1,3,5 2nd Messengers
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IP3/DAG, Gq
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M 2&4 2nd messengers
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decreased cAMP, Gi
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Ipratropium
Route? Tx? Effect? |
M3 blocker
Inhaled Asthma/COPD Bronchodilation & Decreased secretions |
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Cholinergics (7)
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PB N' MACC
Pilocarpine Bethanechol Nicotine Methcholine Acetylcholine Carbachol Cevimiline |
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Atropine
Route? Tx? Effect? |
Non-Sel. Muscarinic Blocker
Oral, Iv, Opth Acute Bradycardia, AV Block, Decrease intraoperative secretions, Adjunct to PAM |
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Tropicamide
Route? Tx? Effect? |
M3 Blocker
Opthalmic Used for pupillary dilation in eye exam Short acting, ok to use in Glaucoma pt. |
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Oxybutinin
Class? Route? Tx? |
M Blocker
PO, Transdermal Treats urinary incontinence/spastic bladder |
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Pancuronium
Class? Tx? Reversal agent? |
Nm blocker (nondepolarizing)
Muscle relaxant Resp. mescles affected Paralysis for surgery or intubation Reverse with Neostigmine |
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Carbachol
Class? Tx? |
NS Cholinergic agonist
Used topically for glaucoma Long acting, resistant to AChE Cont. in asthma |
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Civimeline
Class? Tx? |
NS Cholinergic agonist
Tx Sjogrens Syndrome |
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Pilocarpine
Class? Tx? |
M agonist
Drug of choice for Glaucoma Can worsen ASthma/COPD when PO Not metab. by AChE |
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Bethanechol
Class? Tx? |
M agonist
Increase GI motility, Promote bladder emptying in non-obstructive retention Cont. in asthma |
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Nicotine
Tx? |
Smoking cessation
May cause Tachycardia due to Epi release from Adrenal Desensitization after long use |
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Methacholine
Class? Tx? |
M agonist
Weakly metab. by AChE Diagnosis of asthma "methacholine challenge" |
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AChEi's (8)
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MEN PeePeePIE
Malathion -Insecticide Edrophonium - MG Dx Neostigmine - Post Op Physostigmine - Glaucoma Pyridostigmine - MG Parathion - Toxic Isofluraphate Ecothiophate |
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Malathion
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Irrev. AChEi (insecticide)
Long acting lipid soluble Tx parasites |
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Edrophonium
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AChEi
Short acting (15min.) Dx of Myasthenia Gravis or Over/Undermedication |
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Neostigmine
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AChEi
Medium Acting (1-2 hrs) Reverse non-dep. blockade (panc/roc/vec) Tx postop ileus, Hirschsprungs, Urinary retention |
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Physostigmine
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AChEi
Med. Acting (1-2 hrs.) Opth. drops for Glaucoma |
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Pyridostigmine
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AChEi
Med. Acting Tx of Myasthenia Gravis |
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Parathion
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Irrev. AChEi (Long acting)
Insecticide Toxic to humans No clinical use |
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Ecothiphate
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AChEi
long acting Tx of glaucoma |
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Isoflurophate
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AChEi
Long acting Enters CNS (Crosses BBB) Not used clinically |
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Dyflos
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AChEi
Long acting Opth. drops to treat Glaucoma |
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Organophosphates
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Malathion
Parathion Soman Ecothiophate Isoflurophate |
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ED medications involve what pathway?
What is their action? |
NO mediated smooth muscle realxation
Inhibit PDE5 prolonging smooth muscle relaxation |
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ED medications
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Sildenafil
Tadalafil Vardenafil |
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Physiologic effects of M3 stimulation
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Increased gadtric/salivary secretions
Increased GI motility Ocular accommodation Vasodilation Bronchoconstriction |
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M3 stimulation of eye
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Miosis
Lens thickening |
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Whay are Bethanechol and Methacholine more likely to decrease BP than other Cholinergic agonists?
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Their M3 specificity does not cause Epi release from Adrenal like some non-selective agonists that act on Nicotinic receptors as well
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Atropine effect on eye
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Dilation
Cycloplegia |
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Inhibits choline transporter (CHT)
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Hemicholinium
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Inhibits transport of ACh into vesicle
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Vesamicol
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Enzyme responsible for ACh synthesis
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Choline acetyltransferase (ChAT)
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Inhibits vesicle fusion & release of ACh
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Botulinum toxin
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Histamine
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M3 agonist
Activates IP3/DAG pathway resulting in NO mediated vasodilation Sympathetic inc. in HR is result |
