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46 Cards in this Set

  • Front
  • Back
Acetylcholine
What is it?
Bethanechol
what is it?
Carbachol
what is it?
Edrophonium
What is it?
Methacholine
Resistant to AChE
Pilocarpine
M3 Agonist
Ganglionic Blockers
MeTH

Mecamylamine
Trimethaphan
Hexamethonium
Muscarinic Blockade
Blind as a bat
Hot as hell
Red as a beet
Dry as a bone
Mad as a hatter
Scopolamine
Route?
Tx?
Contrainidications?
Muscarinic Blocker
Oral/Opth/Transdermal
Tx for motion sickness
Contraindicated in Glaucoma
Anticholinergics (8)
PISS BOAT

Pancuronium
Ipratropium
Succinylcholine
Scopolamine
Benztropine
Oxybutinin
Atropine
Tropicamide
M 1,3,5 2nd Messengers
IP3/DAG, Gq
M 2&4 2nd messengers
decreased cAMP, Gi
Ipratropium
Route?
Tx?
Effect?
M3 blocker
Inhaled
Asthma/COPD
Bronchodilation & Decreased secretions
Cholinergics (7)
PB N' MACC

Pilocarpine
Bethanechol
Nicotine
Methcholine
Acetylcholine
Carbachol
Cevimiline
Atropine
Route?
Tx?
Effect?
Non-Sel. Muscarinic Blocker
Oral, Iv, Opth
Acute Bradycardia, AV Block, Decrease intraoperative secretions, Adjunct to PAM
Tropicamide
Route?
Tx?
Effect?
M3 Blocker
Opthalmic
Used for pupillary dilation in eye exam
Short acting, ok to use in Glaucoma pt.
Oxybutinin
Class?
Route?
Tx?
M Blocker
PO, Transdermal
Treats urinary incontinence/spastic bladder
Pancuronium
Class?
Tx?
Reversal agent?
Nm blocker (nondepolarizing)
Muscle relaxant
Resp. mescles affected
Paralysis for surgery or intubation
Reverse with Neostigmine
Carbachol
Class?
Tx?
NS Cholinergic agonist
Used topically for glaucoma
Long acting, resistant to AChE
Cont. in asthma
Civimeline
Class?
Tx?
NS Cholinergic agonist
Tx Sjogrens Syndrome
Pilocarpine
Class?
Tx?
M agonist
Drug of choice for Glaucoma
Can worsen ASthma/COPD when PO
Not metab. by AChE
Bethanechol
Class?
Tx?
M agonist
Increase GI motility, Promote bladder emptying in non-obstructive retention
Cont. in asthma
Nicotine
Tx?
Smoking cessation
May cause Tachycardia due to Epi release from Adrenal
Desensitization after long use
Methacholine
Class?
Tx?
M agonist
Weakly metab. by AChE
Diagnosis of asthma "methacholine challenge"
AChEi's (8)
MEN PeePeePIE
Malathion -Insecticide
Edrophonium - MG Dx
Neostigmine - Post Op
Physostigmine - Glaucoma
Pyridostigmine - MG
Parathion - Toxic
Isofluraphate
Ecothiophate
Malathion
Irrev. AChEi (insecticide)
Long acting lipid soluble
Tx parasites
Edrophonium
AChEi
Short acting (15min.)
Dx of Myasthenia Gravis or Over/Undermedication
Neostigmine
AChEi
Medium Acting (1-2 hrs)
Reverse non-dep. blockade (panc/roc/vec)
Tx postop ileus, Hirschsprungs, Urinary retention
Physostigmine
AChEi
Med. Acting (1-2 hrs.)
Opth. drops for Glaucoma
Pyridostigmine
AChEi
Med. Acting
Tx of Myasthenia Gravis
Parathion
Irrev. AChEi (Long acting)
Insecticide
Toxic to humans
No clinical use
Ecothiphate
AChEi
long acting
Tx of glaucoma
Isoflurophate
AChEi
Long acting
Enters CNS (Crosses BBB)
Not used clinically
Dyflos
AChEi
Long acting
Opth. drops to treat Glaucoma
Organophosphates
Malathion
Parathion
Soman
Ecothiophate
Isoflurophate
ED medications involve what pathway?

What is their action?
NO mediated smooth muscle realxation

Inhibit PDE5 prolonging smooth muscle relaxation
ED medications
Sildenafil
Tadalafil
Vardenafil
Physiologic effects of M3 stimulation
Increased gadtric/salivary secretions
Increased GI motility
Ocular accommodation
Vasodilation
Bronchoconstriction
M3 stimulation of eye
Miosis
Lens thickening
Whay are Bethanechol and Methacholine more likely to decrease BP than other Cholinergic agonists?
Their M3 specificity does not cause Epi release from Adrenal like some non-selective agonists that act on Nicotinic receptors as well
Atropine effect on eye
Dilation
Cycloplegia
Inhibits choline transporter (CHT)
Hemicholinium
Inhibits transport of ACh into vesicle
Vesamicol
Enzyme responsible for ACh synthesis
Choline acetyltransferase (ChAT)
Inhibits vesicle fusion & release of ACh
Botulinum toxin
Histamine
M3 agonist

Activates IP3/DAG pathway resulting in NO mediated vasodilation

Sympathetic inc. in HR is result