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73 Cards in this Set
- Front
- Back
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Cyclopentolate
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synthetic muscarinic antagonist
cycloplegic, mydriatic |
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Ipratropium
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semisynthetic muscarinic antagonist
relieve rhinorrhea, bronchodilator (COPD) |
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Gallamine
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NMJ Blocker
used during surgery to produce muscle paralysis, lack CNS activity |
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Hemicholinium
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Blocks the uptake of choline
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Vesamicol
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increase release of acetylcholine from storage vesicles
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Echothiophate
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Irreversible acetylcholine inhibitor
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Atropine
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natural muscarinic antagonist
treatment of organophospate poisoning |
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MCN-A-343
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Ganglionic nicotinic agonist
experimental drug used to distinguish receptor subtypes |
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Isoflurophate
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Irreversible acetylcholine inhibitor
treatment of glaucoma |
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Tiatropium
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Semisynthetic muscarinic antagonist
relieve rhinorrhea, bronchodilator (COPD) |
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Fosterodine
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Synthetic Muscarinic Antagonist
Treatment of Overactive bladder |
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Bethanechol
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Acetylcholine and choline muscarinic agonist
Treatment of atonic bladder, post-op urinary retention and reflux esophagitis |
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Botulin
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Blocks uptake/storage of acetylcholine in vesicles
Therefore it decreases release of acetylcholine |
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Galantamine
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Reversible acetylcholinesterase inhibitor
Treatment of A.D. |
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Pirenzepine
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M1 antagonist
Treatment of peptic ulcer - reduces acid secretions |
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Organophosphates
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Irreversible Acetylcholinesterase inhibitors
Insecticides, nerve gas |
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Malathion
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Irreversible Acetylcholinesterase inhibitor
Insecticide |
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Methoctramine
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M2 antagonist
CVS failure therapy |
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Edrophonium
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Reversible Acetylcholinesterase inhibitor
Used: diagnostic purpose only for Myasthenia Gravis |
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Pipecuronium
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NMJ blocker - non-depolarizing/competitive inhibitor (steroid)
Long duration of action - 80-180 minutes |
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Pyridine-2-Aldoxime-Methiodide
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Antidote to organophosphorus poisoning
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Hexamethonium
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Ganglionic Nicotinic Antagonist
Treatment of HTN - occupies sites on ion channels (not receptor) |
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MNPV
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Inhibits the synthesis of choline transferase
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Arecholine
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Naturally occuring cholinomimetic alkaloid (muscarinic agonist)
Uses - opthalmic purposes |
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Mecamylamine
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Ganglionic nicotinic antagonist
Uses - treatment of HTN, SMOKING CESSATION, tertiary amine designed to improve absorption verses the quats |
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Scopolamine
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Natural Muscarinic Antagonists
Uses - reduce tremors (in parkinson's disease), preanesthetic sedation, motion sickness, emesis, mydriasis and cycloplegia |
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Tolterodine
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Synthetic Muscarinic Antagonist
Uses - overactive bladder |
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Mivacurium
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NMJ Blocker - Non-depolarizing/competitive antagonist (benzylisoquinoline)
Short duration (12-18 minutes) METABOLIZED BY CHOLINESTERASES |
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ABT-418
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CNS Nicotinic Agonist
Used - Neuropathic pain (analgesic) |
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Tetraethylammonium
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Ganlionic Nicotinic Antagonist
Uses - treatment of HTN, Short duration of action |
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Oxybutynin
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Synthetic Muscarinic Antagonist
Treatment of Overactive Bladder |
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Spider Venom
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Increases the release of acetylcholine
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Trospium
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Synthetic Muscarinic Antagonist
Used in overactive bladder |
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TMA
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Ganglionic nicotinic agonist
Experimental, used to distinguish receptor subtypes |
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Darifenacin
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M3 antagonist
Treament of Overactive Bladder |
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Atracurium
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NMJ blocker - nondepolarizing/competitive antagonist (benzylisoquinoline)
Adjunct to general anesthesia, facilitates intubation and skeletal muscle relaxation (intermediate duration -30 to 90 min) |
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Epibatidine
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CNS Nicotinic Agonist
Treatment of Neuropathic pain (analgesic) |
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SIB-1508Y
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CNS Nicotinic Agonist
Treatment of Parkinson's disease |
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Demecarium
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Semireversible acetylcholinesterase inhibitor
Treatment of glaucoma, accommodative estropia (crossing ofthe eyes due to far-sightedness) |
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Rivastigmine
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Semireversible acetylcholinesterase inhibitor
Treatment of A.D. |
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Doxacurium
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NMJ Blocker - nondepolarizing/competitive inhibitor (benzylisoquinoline)
Long duration of action (80-180 min) |
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DPI
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Ganlionic nicotinic agonist
Experimental drug that distinguishes receptor subtypes |
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Solifenacin
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M3 antagonist
Treatment of overactive bladder |
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Homatropine
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Semi-synthetic muscarinic antagonist
induces mydriasis and cycloplegia |
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Pyridostigmine
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Semi-reversible acetylcholinesterase inhibitor
Treatment of Myasthenia gravis, used against various toxin induced toxicity in military |
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Trihexiphenidyl
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Synthetic Muscarinic Antagonist
Treatment of Parkinson's Disease |
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Telenzepine
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M1 antagonist - more potent than others in this class
Reduces gastric acid secretion - used to treat peptic ulcer |
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AF267B
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Synthetic Muscarinic Agonist (lipophilic)
Treatment of A.D. |
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Tacrine
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Reversible Acetylcholinesterase inhibitor
Treatment of A.D. Off market because of hepatotoxicity |
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Ambenonium
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Reversible Acetylcholinesterase inhibitor
Treatment of NMJ disorder - Myasthenia Gravis |
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Physostigmine
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Semireversible acetylcholinesterase inhibitor
Treatment of glaucoma, miotic agent, reverse antagonist - induced toxicity |
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Benztropine
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Synthetic Muscarinic Antagonist
Treatement of P.D. |
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Vecuronium
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NMJ blocker - non-depolarizing/competitive inhibitor (steroid)
Intermediate duration (30-90 min) |
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Rapcuronium
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NMJ Blocker - non-depolarizing/competitive inhibitor (steroid - short acting)
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Cevimiline
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Synthetic Muscarinic Agonist
Treatment of Sjogrens Syndrome (dry mouth and dry eye treatment) |
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Tropicamide
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Synthetic Muscarinic Antagonist
Treatment of cycloplegic; mydriatic |
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Trimethaphan
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Ganglionic Nicotinic Antagonist
AntiHTN, aortic aneurysm, HTN emergency, short acting, orally inactive (IV only); occupies receptor (not ion channel) so can be overcome by more acetylcholine |
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Donepezil
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Reversible Acetylcholinesterase inhibitor
Treatement of A.D. |
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Hemicholiniums
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Choline uptake inhibitors
Inhibit acetylcholine synthesis |
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Propenthaline
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Synthetic Muscarinic Antagonist
Peptic Ulcer, hyperhydrosis |
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Verenicline
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CNS Nicotinic partial agonist and nicotinic antagonist
Synthetic smoking cessation |
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Neostigmine
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Semireversible acetylcholinesterase inhibitors
Treatment of MG, post-op distention and urinary retention, paralytic ileus, antidote fornon-depolarizing neuromuscular blocking agent after surgery |
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Vesamicol
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Decrease acetylcholine release by decreasing storage (empty vesicles release)
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Pancuronium
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NMJ Blocker - nondepolarizing/competetive inhibitor (steroids)
Long duration (80-180) |
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Pilocarpine
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Naturally occuring cholinomimetic alkaloid (muscarinic agonist)
Treatment- IOP, Sjogren's Syndrome |
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Rocuronium
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NMJ Blocker - Non-depolarizing/competetive inhibitor (steroid)
Intermediate duration - (30-90) |
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Carbachol
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Acetylcholine and choline muscarinic agonist
Treatment - induces miosis during surgery |
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MNPV
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Chat inhibitor
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Decamethonium
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NMJ Blocker - depolarizing/non-competitive inhibitor
Used during surgery |
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Tubocurarine
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NMJ Blocker - non-depolarizing/competitive inhibitor
Long duration (80-180 min.) |
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Succinylcholine
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NMJ blocker - depolarizing/non-competitive
Ultra-short duration (5-8 min), dicholine ester |
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Cyclopentolate
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Synthetic Muscarinic Antagonist
Cycloplegic, mydriatic |
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Ipratropium
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Semisynthetic muscarinic antagonists
Relieve rhinorrhea, bronchodilator (COPD) |
