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20 Cards in this Set
- Front
- Back
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Carbachol
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Muscarinic agonist
Not a substrate for AChE Reduces IOP in Glaucoma |
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Pilocarpine
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Muscarinic Agonist
Profound effect on sweat glands (+) Ophthalmic solutions for Glaucoma |
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Bethanachol
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Muscarinic Agonist for GI/GU tract
Gets things going again Nonobstructive urinary retention Not used when strength of GI/GU tract is in question or in case of obstruction |
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Neostigmine
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AChE inhibitor
Increases amount of ACh in synapse at given time Symptomatic control of Myasthenia Gravis Antidote for non-depol. neuromuscular blocking agents |
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Edrophonium Chloride
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AChE inhibitor
Used to make differential diagnosis of Myasthenia Gravis |
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Physostigmine
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AChE inhibitor that can work in the CNS (unlike Neostigmine)
Used to reverse the effects of centrally-acting Muscarinic Antagonists (Antihistamines and Antidepressants that exhibits anti-cholinergic effects) Reverses effects of sedatives like Diazepam |
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Isoflurophate (DFP)
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Irreversible AChE inhibitor
Used in opthalmic solutions for Glaucoma Toxic derivatives used in insecticides |
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Atropine in Cardiology
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Muscarinic Antagonist at M2
Reverse excess vagal tone after MI Reduce brady associated with hyperactive carotid Decreases amount of AV block produced by digitalis Low dose activates vagal tone decreases SNS tone during MI |
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Ipratropium Bromide
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Muscarinic Antagonist
Bronchial smooth muscle Causes bronchodilation |
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Propantheline Bromide
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Muscarinic Antagonist
Used to treat peptic ulcers |
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Pirenzepine
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M1 Muscarinic Antagonist
Used to treat gastric ulcers without atropine-like SEs like tachycardia, blurred vision and constipation |
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Darifenacin
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Highly M3 selective Muscarinic Antagonist
Used to treat incontinence Increases warning time by 4.3 minutes |
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Hexamethonium
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Nicotinic receptor antagonist
One of first treatments for hypertension |
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Trimethaphan
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Short acting nicotinic antagonist
Used in hypertensive emergencies when Beta blockers are contraindicated (ex. DAA) |
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Mecamylamine
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Nicotinic antagonist within CNS
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Botulinum Toxin
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Presynaptic receptor antagonist
Prevents ACh release |
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Succinylcholine
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Depolarizing neuromuscular blocking agent
Binds nicotinic receptors on motor end plate Depolarization is followed by desensitization Metabolized by pseudocholinesterase in 3-5 min. |
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Tubocurarine
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Non-depolarizing competitive nicotinic antagonist for motor end plate
Overcome with more ACh Can also block autonomic ganglia and release histamine (hypotension) |
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Baclofen
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Centrally acting muscle relaxant
GABA derivative that stimulates GABA inhibitory receptors CNS depressant |
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Diazepam
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A benzodiazepine that causes increased binding of GABA to its receptor
Sedative, Hypnotic, Anti-anxiety |
