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12 Cards in this Set
- Front
- Back
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What type of response do cholinergic drugs produce?
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Same physiological responses as the neurotransmitter ACh
Increase synthesis, release and reduce catabolism of ACh |
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What does the drug Donepezil (Aricept) do?
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First drug approved by FDA for ALL degrees of AD type dementia
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What are some direct acting cholinergic drugs and what do they do?
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Direct stimulation of cholinergic receptors
Synthetic (esters of choline): Bethanechol and Carbachol Natural: Acetylcholine and Cholinemimetic alkaloids (pilocarpione and Nicotine |
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What are examples of indirect acting cholinergic drugs and how do thye work?
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Elevate endogenous levels of ACh
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How does ACh work, what is it used for and for how long and ADR's?
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Clinical use is a minimal, very short duration, nonspecific (affects all cholingeric receptors)
For intraocular use, contracts smooth muscle of iris for ocular surgury (cataracts) Burning, itching, headache |
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What is Carbachol used for, how does it work, what does it do?
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For intraocculr/pupilary surgury
Has a nitrogen substitue which reduces its interaction with cholinesterase and making it last longer |
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What is Isopto Carbachol used for and how does it work?
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Topical treatment for open-angle glaucoma
Facilitates outflow of aqueous humor Most potent direct-acting cholineric drug |
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What are the ADR's of direct acting cholingeric drugs?
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sweating, flushing, headache, cillary spasm with decreased vision (temporary), cramping, urinary urgency (b/c they increase GI activity and urinary function)
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What are the contraindications for direct acting Cholingeric drugs?
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Corneal abrasions, acute iritis
Precautions necessary for asthma, peptic ulcer, GI, urinary distress |
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What is Bethanechol used for, the ADR, Contraindications?
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Treatment of NONOBSTRUCTIVE urinary retention, neurogenic atony of urinary bladder
ADRs same as cholingeric receptors do Peptic ulcer, asthma, coronary artery disease, AV conduction problems, parkinson, pregnancy, urinary obstruction |
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What is a major contraindication for Cholingeric drugs?
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Do not use with parkinsons b/c it will make it worse, Anticholingeric drugs are used in early parkinson
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What is Pilocarpine used for,how does it work, ADR, and contraindications?
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It is a natural product for open angle glaucoma, narrow angle glaucoma prior to surgury and Reversal of cycloplegics and mudriatics after eye exam or surgury
It is a cholinomimetic alkaloid the has direct cholinergic receptor activation Cilliary spasm, headache, difficult focusing, provocation of asthma Contraindicated in acute iritis and inflammatory conditions of anterior chamber |
