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10 Cards in this Set

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Mivacurium
Non depolarizing competitive nAChR antagonist
Fast onset/duration
Metabolised by plasma esterase
Main side effect: transient hypotension
Similar action to succinylcholine
Longer duration of action
Rocuronium
Non-depolarizing nAChR antagonist
Fast onset/ 45 min duration of action
Metabolized in liver, excreted by kidney
Slight effect on heart rate
Vecuronium
Non-depolarizing competitive nAChR antagonist
Intermediate onset and duration of action
Liver and kidney deacylation
Pancuronium
Intermediate onset
Long duration of action
Non-depolarizing competitive nAChR antagonist
Moderate block of Cardiac mAChR
Kidney deacylation
Widely used in surgery - long duration
Cisatracurium
Slow onset
Intremediate duration
Spontaneous hydrolysis in plasma
Slight histamine release
Widely used in surgery
Bad for asthmatics
Concern about hypotension and bronchoconstriction
Atracurium
Slow onset / Intermediate duration
Spontaneous hydrolysis in plasma
Low histamine release
Degradation slowed by acidosys
Pipecuronium
Short onset
Long duration
Kidney deacetylation
Not for kidney transplant
Metocurine
Slow onset . Long duration
Blockade of nAChR antagonist
Tobocurarine
Slow onset
long duration
Insignificant metabolism
Blockade of nAChR antagonist
HIGH histamine release / no longer used clinically
Doxacurium
Slow onset / long duration
None of anything
Non-depolarizing competitive nAChR antagonist