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21 Cards in this Set

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  • Back
Lovastatin (Mevacor)
Lipid-lowering: Statins
Lowering of total LDL and triglycerides. Slightly increases HDL. S/E Abdom. cramps;dizziness
Lipid lowering agent, statin:
inhibits 3-hydroxy-3-methylglutaryl-coenzyme. Lowers total and LDL and increases HDL: S/E, cramps, dizziness
Simvastatin (Zocor)
Lipid lowering: statin
inhibits 3-hydroxy-3-methylglutaryl-coenzyme.A enzyme which is responsible for catalyzing an early step in the synthesis of cholesterol. S/E Rash, cramps
Fluvastatin (Lescol)
Lipid lowering; statin,
inhibits 3-hydrolxy-3-methylglutaryl-coenzyme A: headache,nausea,rhabdomyolysis
Lipid lowering: Statin
inhibits 3-hydroxy-3-methylglutaryl-coenzyme A:
S/E cramps,rash,rhabdomyolysis,rashes,hypersensitivity reactions including edema.
Cholestrol Lowering Drugs:
Blocks the enzyme 3-hudroxy-3-methylglutaryl-coenzyme(involved in chol. synthesis)in the liver.
1st line of treatment for elevated LDL.
S/E may cause increase serum liver enzyme levels adn myopathy
Statins(Nursing responsibilty)
Monitor serum choloesterol and liver enzyme levels before and during therapy.
Assess pain and muscle tenderness.
Statins: Family teaching
Promptly report muscle pain, abdominal pain,tenderness,changes in skin color.
Grapefruit and grapefruit juice may interact w/statins this interaction could be dangerous.
Cholesterol-lowering drugs:
Bile Acid Sequestrants
Bile Acid Sequestrants
Binds to choloesterol in GI tract.
Primary disadvantages are inconvenience of administration due to bulk&gastrointestinal s/e such as constipation.
Bile Acid Sequestrants:
Nursing Responsibilities
Mix powders w/4-6 ounces of water or juice,administer once or twice a day as ordered w/meals.
Bile Acid Sequestrants:
Client&Family teaching
Promptly report constipation, severe gastric distress w/nausea&vomiting, unexplained wt. loss, black/bloody stools
Cholesterol-Lowering drugs:
Nicotinic Acid
Cholesterol-Lowering Drug
Nicotinic Acid
Lowers total LDL and cholesterol and triglyceride levels
Nicotinic Acid
Because the doses req. for it to work with mulitiple s/e. The drug is used in combo with statin drugs.
Nicotinic Acid
Nursing responsibilities
Give PO w/ meals & cold drink to lower GI effects.
Administer w/ caution to pt. w/active liver disease,peptic ulcer,gout,or type 2DM
Monitor BGT,uric acid level and liver function tests.
Nicotinic Acid
Pt. and Family teaching
Flushing for face, neck &ears may occur within 2hrs. following dose, these effects generally subside as treatment continues. Alchol may worsen effect.
Report weakness or diziness w/changes in posture(lying to sitting: sitting to standing) to MD. Change positions slowly to reduce the risk of injury.
Cholesterol lowering Drug
Fibric Acid Derivatives
Fibric Acid Derivative
Used to lower serum triglyceride levels; they have only a slight to modest effect on LDL
Affect lipid regulation by blocking triglyceride synthesis.
Used to treat very high triglyceride levels adn may be used in combo w/statins.
Fibric Acid Derivative
Nursing Responsibilites
Monitor serum LDL levels, liver enzymes & renal funtion tests during therapy. Report abnormal findings.
Up to 2 months of treatment maybe required to achieve a therapeutic effect, rebound w; decreasing benefit, may occur in the 2nd or 3rd month of treatment.
Fibric Acid Derivative
Pt. Client teaching
Take w/meals if drug causes gastric effect.
Promptly report flukike symptoms to MD.
Contact MD before stopping this drug and before taking any OTC preparations.