Cholesterol Lower Drugs Statins

Front 1

Lovastatin (Mevacor)

Back 1

Lipid-lowering: Statins
Lowering of total LDL and triglycerides. Slightly increases HDL. S/E Abdom. cramps;dizziness

Front 2

Pravastatin(Pravachol)

Back 2

Lipid lowering agent, statin:
inhibits 3-hydroxy-3-methylglutaryl-coenzyme. Lowers total and LDL and increases HDL: S/E, cramps, dizziness

Front 3

Simvastatin (Zocor)

Back 3

Lipid lowering: statin
inhibits 3-hydroxy-3-methylglutaryl-coenzyme.A enzyme which is responsible for catalyzing an early step in the synthesis of cholesterol. S/E Rash, cramps

Front 4

Fluvastatin (Lescol)

Back 4

Lipid lowering; statin,
inhibits 3-hydrolxy-3-methylglutaryl-coenzyme A: headache,nausea,rhabdomyolysis

Front 5

Atorvastatin(Lipitor)

Back 5

Lipid lowering: Statin
inhibits 3-hydroxy-3-methylglutaryl-coenzyme A:
S/E cramps,rash,rhabdomyolysis,rashes,hypersensitivity reactions including edema.

Front 6

Cholestrol Lowering Drugs:
Statins
Action

Back 6

Blocks the enzyme 3-hudroxy-3-methylglutaryl-coenzyme(involved in chol. synthesis)in the liver.
1st line of treatment for elevated LDL.
S/E may cause increase serum liver enzyme levels adn myopathy

Front 7

Statins(Nursing responsibilty)

Back 7

Monitor serum choloesterol and liver enzyme levels before and during therapy.
Assess pain and muscle tenderness.

Front 8

Statins: Family teaching

Back 8

Promptly report muscle pain, abdominal pain,tenderness,changes in skin color.
Grapefruit and grapefruit juice may interact w/statins this interaction could be dangerous.

Front 9

Cholesterol-lowering drugs:
Bile Acid Sequestrants

Back 9

Cholestyramine(Questran)
Colestipol(Colestid)
Colesevelam(Welchol)

Front 10

Bile Acid Sequestrants
Action:

Back 10

Binds to choloesterol in GI tract.
Primary disadvantages are inconvenience of administration due to bulk&gastrointestinal s/e such as constipation.

Front 11

Bile Acid Sequestrants:
Nursing Responsibilities

Back 11

Mix powders w/4-6 ounces of water or juice,administer once or twice a day as ordered w/meals.

Front 12

Bile Acid Sequestrants:
Client&Family teaching

Back 12

Promptly report constipation, severe gastric distress w/nausea&vomiting, unexplained wt. loss, black/bloody stools

Front 13

Cholesterol-Lowering drugs:
Nicotinic Acid

Back 13

Niacin(Nicobid,Niaspan)

Front 14

Cholesterol-Lowering Drug
Nicotinic Acid
Action

Back 14

Lowers total LDL and cholesterol and triglyceride levels

Front 15

Nicotinic Acid
Action

Back 15

Because the doses req. for it to work with mulitiple s/e. The drug is used in combo with statin drugs.

Front 16

Nicotinic Acid
Nursing responsibilities

Back 16

Give PO w/ meals & cold drink to lower GI effects.
Administer w/ caution to pt. w/active liver disease,peptic ulcer,gout,or type 2DM
Monitor BGT,uric acid level and liver function tests.

Front 17

Nicotinic Acid
Pt. and Family teaching

Back 17

Flushing for face, neck &ears may occur within 2hrs. following dose, these effects generally subside as treatment continues. Alchol may worsen effect.
Report weakness or diziness w/changes in posture(lying to sitting: sitting to standing) to MD. Change positions slowly to reduce the risk of injury.

Front 18

Cholesterol lowering Drug
Fibric Acid Derivatives

Back 18

Gemfibrozil(Lopid)
Fenofibrate(Tricor)
Clofibrate(Atromid-S)

Front 19

Fibric Acid Derivative
Action

Back 19

Used to lower serum triglyceride levels; they have only a slight to modest effect on LDL
Affect lipid regulation by blocking triglyceride synthesis.
Used to treat very high triglyceride levels adn may be used in combo w/statins.

Front 20

Fibric Acid Derivative
Nursing Responsibilites

Back 20

Monitor serum LDL levels, liver enzymes & renal funtion tests during therapy. Report abnormal findings.
Up to 2 months of treatment maybe required to achieve a therapeutic effect, rebound w; decreasing benefit, may occur in the 2nd or 3rd month of treatment.

Front 21

Fibric Acid Derivative
Pt. Client teaching

Back 21

Take w/meals if drug causes gastric effect.
Promptly report flukike symptoms to MD.
Contact MD before stopping this drug and before taking any OTC preparations.