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12 Cards in this Set
- Front
- Back
- 3rd side (hint)
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ApoA-I is associated with which lipoprotein(s)? What is its function?
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HDL
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-picks up cholesterol and loads into HDL
-activates LCAT -interacts with ABC transporter |
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ApoA-II is associated with which lipoprotein(s)?
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HDL
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ApoA-IV is associated with which lipoprotein(s)?
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-chylomicrons
-HDL |
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ApoB-48 is associated with which lipoprotein(s)?
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chylomicrons
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ApoB-100 is associated with which lipoprotein(s)? What is its function?
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-VLDL
-LDL |
-recognized by LDL receptors on cell surface
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ApoC-I is associated with which lipoprotein(s)?
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-VLDL
-LDL |
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ApoC-II is associate with which lipoprotein(s)? What is its function?
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-HDL
-VLDL -chylomicrons |
-activates lipoprotein lipase
-exchanged from chylomicrons to HDL in circulation, then cycled back to chylomicrons later |
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ApoC-III is associated with which lipoprotein(s)? What is its function?
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-chylmicrons
-VLDL -HDL |
-inhibits lipoprotein lipase
-exchanged from chylomicrons to HDL in circulation, then cycled back to chylomicrons later |
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ApoD is associated with which lipoprotein(s)?
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-HDL
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ApoE is associated with which lipoprotein(s)?
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-chylomicrons
-VLDL -HDL |
-triggers clearance of VLDL and chylomicrons when there's no more TG
-exchanged from chylomicrons to HDL in circulation, then cycled back to chylomicrons later |
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What is the committed step in formation of cholesterol?
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HMG-CoA reductase
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How is cholesterol synthesis regulated?
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-phosphorylation of HMG-CoA reductase enhanced by glucagon (deactivate)
-dephosphorylation of reductase enhanced by insulin (reactivate) -statin and cholesterol derivatives bind to substrate binding site of reductase cholesterol binds to LXR which activates 7a-hydrolase to synthesize bile salts from excess cholesterol -cholesterol binds SREBP and binds to LDL receptors and/or inhibits biosynthesis of reductase -cholesterol turns on ACAT to induce cholesterol storage |
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