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22 Cards in this Set

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  • Back
Describe the structure of the 5 lipoproteins.

Lipoproteins are cholesterol coated carries of ________& _________. They have a integral _________ that determines their function
triacylglycerols
cholesterol esters
apolipoprotien
the NIH derived desirable level for cholesterol is ____
<200
the NIH derived desirable level for LDL is ____
<100
the NIH derived desirable level for for HDL is ____
>60
the disease associated with increased plasma cholesterol levels is _________
coronary heart disease
Chylomicron carries ________ and uses apoprotien ____ to signal lipoprotein lipase activation
dietary triglycerides
C-II
LDL carries _______ and uses apoprotien ____ to bind to the liver and other tissues
cholesterol esters
B-100
HDL carries _____ to the liver and uses apoprotien __ to activate LCAT, esterifies cholesterol within in plasma
cholesterol esters
A-1
______ attached to LDL is a cardiac Risk Factor
Lipoprotein A
Patient resistant to treatment continues to have greatly increased triglycerides. What type of inherited hyperlipoproteinemia is this? What is the associated genetic disorder?
type I
Apo C-II deficiency
Patient resistant to treatment shows normal triglycerides, but high cholesterol & LDL What type of inherited hyperlipoproteinemia is this? What is the associated genetic disorder?
type II
LDL receptor deficiency
In class I familial hypercholesteremia (Type II) LDL receptor ______ is defective.
synthesis
In class II familial hypercholesteremia (Type II) processing of the receptor in the ______ is defective.
Golgi
In class III familial hypercholesteremia (Type II) there is a ______receptor.
non-functional
In class IV familial hypercholesteremia (Type II)_______ is defective
internalization
Describe the structure of the lipoproteins.
Lipoproteins are cholesterol coated carries of triacylglycerols & cholesterol esters. They have a integral apolipoprotien that determines their function
Describe Chylomicrons
carries dietary triglycerides and uses apoprotien C-II to signal lipoprotein lipase activation
Describe LDL
cholesterol esters and uses apoprotien B-100 to bind to the liver and other tissues
Describe HDL
cholesterol esters to the liver and uses apoprotien A-1 to activate LCAT, esterifies cholesterol within in plasma
Identify the risk factor associated with high levels of lipoprotein A.
attached to LDL is a cardiac Risk Factor
Identify the biochemical lab findings of Hyperlipoproteinemia Type 1 & 2
Hyperlipoproteinemia Type 1 =high triglyceride

Type 2 =normal triglycerides, high total cholesterol and LDL
Recognize the mechanism of the Type II (Class 1-4) hyperlipoproteinemias.
In class I familial hypercholesteremia (Type II) LDL receptor synthesis is defective.
In class II familial hypercholesteremia (Type II) processing of the receptor in the Golgi is defective.
In class III familial hypercholesteremia (Type II) there is a non-functional receptor.
In class IV familial hypercholesteremia (Type II) internalization is defective