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5 Cards in this Set
- Front
- Back
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Statin Rx function
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Competitive inhibitor HMG-CoA reductase
Decreased cholesterol synthesis Boost ApoA1 (HDL) synthesis |
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Ezetimbe
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Lowers intestinal absorption dietary cholesterol.
Can be prescribed conjunction with statins |
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Fibrates
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Lower circulating triglyceride conc.
Improve HDL Unknown mech |
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Nicotinic Acid
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Increases circulating HDL
May lower circulating LDL Mech - decrease FA release from adipose tissue leading to lower availability TAG & cholesterol for VLDL synthesis |
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Bile Acid Sequestering Resins
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(double lines are actually arrows)
reduced recycling lowers liver bile salt concentration lowers feedback repression increases hydroxylase activity increases cholesterol conversion to bile acids lowers cholesterol concentration more LDL receptors increased hepatic uptake of LDL lowers plasma cholesterol SE: increase triglycerides & causes abdominal fullness |
