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67 Cards in this Set

  • Front
  • Back
Growth vs Development
Growth - Increase in size & Number

Development - Increase in organization or complexity

- Closely related, but not synonymous
Growth pattern pre and post natal
Fetal head is 50%
Birth head is 30%
Adult head is 15%

More growth of lower limbs than upper limbs during post natal life reflecting Cephalocaudal gradient of growth.
Three possibilities for growth
Hypertrophy - Increase in Size

Hyperplasia - Increase in number

Secretion of ECM - important in skeletal system
Interstitial vs Appositional growth
Interstitial - Found in nearly all soft tissue and uncalcified cartilage. Growth in length

Appositional growth - Mineralization on the surface occurs so that hard tissue is formed. Deposition of new bone by cells in periosteum. Increased bone width.
Intramembranous bone formation
Formation by direct secretion of bone matrix
- Predominant mecanism in skull

Undifferentiated mesenchymal cells can become osteoblasts to deposit first fibrous bone matrix called Osteoid & mineralization occurs almost immediately.
- Some osteoblasts continue to secrete bone matrix, others become surrounded by their own deposits and become osteocytes.
Endochondral bone formation
Bone begins as cartilaginous matrix surrounded by perichondrium except at ends

- Long bones associated with movable joints
- Mandibular condyle
- Bones of cranial base
- Middle ear ossicles

Hypertrophy of chondrocytes occur in primary ossification center, and blood vessels from pericondrium erode into mineralized are and brings in vessels carrying sheath of undifferentiated mesenchymal tissue. Some cells become osteoblasts to form bone.
Bone remodeling
Asspositional growth at periosteal surface and resorption at endosteal surface.

Drift
Displacement
Relocation
Vital staining
Ingest certain chemicals which are incorporated into developing bone.

Alizarin sulfonate - chelates with inorganic portion of bone
Procion - Organic phase of bone
Tetracycline - absorbed by mineralizing tissues and will fluoresce under UV light
Radioisotopes
Injected into living test animals and become incorporated into bone undergoing growth or remodeling.
- Ca45
- P32
- Proline H3, found in hydroxyproline component of developing collagen fibers of osteoid matrix
Implants
Titianium pellets implanted into the facial area as radio-opaque reference points for cephalometric analysis. Compare between first and succeding xrays
Comparative anatomy
Study of other species and infer information to humans
Cephalometrics
Used in ortho to aid in diagnosis and treatment planning. Indicates relative amt and direction of craniofacial growth in 2 dimensions
Natural markers
Examine persistence of developmental features such as trabeculae and lines of arrested growth
3 theories on determinants of craniofacial growth
Bone is primary determinant
Cartilage is and bone responds secondarily and passively
Soft tissue matrix is, and both bone & cartilage are secondary

When bone responds passively, its called Epigenetic. First theory has largely been tossed
Sicher's theory
- Growth of skull is controlled mainly by intrinsic genetic factors
- Only surface remodeling is influenced by local environmental factors such as muscle forces
- paired parallel sutures push nasomaxillary complex downard to match mandiblular growth
Scott's nasal septal theory
- Intrinsic genetic factors operate only on cartilage and periosteum and cartilaginous parts of skull are centers of growth with nasal septum as the major contributor/pacemaker of maxillary growth.

- Thus, Craniofacial growth is coordinated because sutural growth is responsive to growth of synchondroses.
Enlow's V principle
Many facial & Cranial bones have V shape and deposition occurs on inner side whereas resorption occurs on other side.

Overall increase in dimensions
Moss's Functional Matrix theory
No intrinsic genetic growth mechanism in skull
- Growth depends on bony components of skull is determined by growth and function of other factors such as muscles, tongue, eyes, brain etc.
Van Limborgh's theory
Mixes others

- Growth and ossification of skull parts is controlled by intrinsic genetic factors
- Therefore follows a path and cannot be affected
- Desmocranium and structures adjacent to head is a source of epigenetic influences
- Extent of influences from epigenetic factors depends on intensity of influences
2 primary components of cranium
Desmocranium - earliest mesenchymal precursor to cranial vault. Develops via intramembranous. Starts 1st month in utero, occipital first then parietal & frontal

Chondrocranium - Embryonic cartilaginous cranium. Develops via endochondral
Calvaria bone growth
Thickens with age due to deposition on both periosteal & meningeal surfaces
- Medullary endosteal sorfaces are resorptive
Fontanelles & Closures
Fibrous tissue membranes that exist at angles of parietal bone to allow skull to pass through birth & accomodate brain.

6 total
Anterior
Posterior
2 Sphenoid
2 mastoid

Sphenoid & Posterior close at 2-3 months, Mastoid at 12mths, Anterior at 18months
- Cranial growth occurs through 7yr which is when cranial vault reaches adult dimensions
Sutures
Metopic of frontal suture
Saggital suture
Labdoid suture
Coronal suture
Squamous suture
Craniofacial synostosis
Premature fusion of 1 or more cranial sutures/fontanelles

Scaphocephaly - Saggital suture
Anterio plagiocephaly - one coronal suture
Brachycephaly - both coronal sutures
Posterior plagiocephaly - one lambdoid suture
Trigonocephaly - early fusion of metopic suture
Crouzon syndrome
- Most common craniofacial syndrome
- Skull is typically brachycephalic with prominent nose & protruding jaw
- Exopthalmos
- Hydrocephalus
Apert syndrome
- Second most common syndrome after Crouzon
- High brachycephaly and severe syndactyly
- Clefts of soft palate & uvula are often.
- Hands and feet show bony fusion
Development of Chondrocranium
Limited to cranial base starting at second month in utero starting first at occipital plate.
Major portion of increased length and age of growth
Major portion of increased length occurs at cartilaginous joints between ethmoid, sphenoid & occipital bones.

Continues till 18-25
Development of maxilla
Arise as 2 separate bones and begins intramembranous ossification at 6th wk.

Growth occurs 2 ways:
Apposition of bone at sutures that connect maxilla to cranium & Surface remodeling
Embryo development
7 Processes
1 Median nasal process
2 Lateral Nasal process
2 Maxillary and 2 Mandibular processes all from first branchial arch
Formation of the Palate
Occurs 5-6week
- Fusion of median nasal process gives rise to upper lip, anterior part of alveolar process of maxilla, & anterior portion of palate

Secondary Palate - Fusion of palatine shelves of maxillary process forms incisive foramen
Cleft lip & Palate
Cleft lip 4-7 week
- Failure of fusion of medial nasal & Maxillary processes usually on left.

Cleft palate 6-10 wks
- Failure of palatine shevesl of maxillaru process to fuse
Cephalometric radiograph & age determination
Analysis of cervical vertebrae 2-4 will show visible concavity at lower border of C3 immediately preceding peak in mandibular growth. Will occur 1 year after this stage.
Variations in eruption sequence with clinical significance
Eruption of mandibular 2nd molars ahead of premolars can block 2nd premolar out of arch

Eruption of Maxillary canines ahead of premolars can force canine out labially

If permanent tooth on one side erupts but counterpart does not within 6 months, should take radiograph to investigate
Variation in Suckling & Swallowing
Infant - Active contraction of lips with little activity of posterior tongue or pharyngeal muscles.

Adult - Lips relaxed, posterior teeth into contact
Variation in mastication
Child - mandible moves laterally during opening then back to midline on closing. Pattern transition in conjunction of permanent canine eruption

Adult - Mandible opens straight down then moves jaw laterally to bring teeth into contact
Speech variations
1st sounds - Bilabial p, b
Tongue tip - t, d
Sibilant - s, z Tongue tip close but not against palate
Last speech sound - r 4-5
Stages of adolescence in girls
I - Beginning: Breast buds & Early pubic hair
II - 1 yr after: Peak velocity
III - 1-1.5yr after stage 2: Menstruation, broadening of hips with adult fat distribution.
Stages of adolescence in boys
I: Fat spurt: Increase in size & pigmentation change in scrotum
II: 1 yr after: Pubic hair, penis growth
III: 8-12 months after peak velocity, upper lip hair, muscle
IV: 14-24 mths after: Spurt complete, facial hair,
Growth of nasomaxillary complex
1) Passive displacement - growth in cranial base pushes maxilla forward. Important during primary dentition years

2) Active growth of maxillary structures and nose. Downward and forward growth of maxilla
Mandibular growth
Ramus hight 1-2mm/yr
Body length 2-3mm/yr

Increase in chin prominence - variable due to glenoid fossa growth
Timing of growth in width length and height
Width first then length and then height

- Maxillary down and forward growth complete at 14-15. 2-3yrs after 1st menstruation
Bjork
Internal rotation - Rotation that occurs at core of each jaw

External rotation - Surface changes and alterations in the rate of tooth eruption

Total - Internal - External rotation
Maxillary jaw rotation
Core rotates slightly forward internal

Bone resorption on nasal side & apposition on palatal side is external

Cancel each other out
Short face type
Excessive forward rotation of mandible - too much internal rotation

- Deep bite & crowded incisors. Brachycephalic
Long face type
Porsterior downard rotation of palatal plane.

Decrease internal rotation of mandible and increase mandibular plane angle

Anterior open bite & mand deficiency. Dolicocephalic
Facial growth in adults
Vertical>AP>Width

Male: Forward rotation tendency to decrease mandibular plane angle

Female: Backward rotation tendency for increase mandibular plane angle
Edward H. Angle's beliefs & Paradigm shift
Maxillary first molars were key to occlusion

Shift:
- Greater emphasis on dental and facial appearance
- Patients are more involved in planning their treatment
- Older patients being treated require multidisciplinary approach
Normal overjet & Overbite
Normal overjet: 2-3mm

Normal overbite: 1-2mm
% of children falling into angle's 4 groups
30% Normal
50-55% Class I
15% Class II
<1% Class III
Prevalence of Malocclusion
African Americans likely to have diastema & open bite

Whites have more severe deep bites and more class II

Asians have more class 3

Hispanics have more severe class 3 but less vertical problems
Primate Spaces
Maxilla: Lateral to canine
Mandible: Canine & First molars
Development of occlusion
Birth - 6months: Edentulous
6 month-2yr: Eruption of primary
2yr-6yr : Full primary
6-12yr: Mixed dentition
When does permanent teeth erupt? & desired sequence
Begins at 6 and when 3/4 of root is formed

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Eruption steps
Preemergent eruption
- Resorption of bone(Rate limiting) & resorption of primary roots
- Eruption mechanism itself then moves where path was cleared

Eruption movement then occurs after root formation. This supports idea that PDL metabolic activity plays major role
Cleidocranial dysplasia
Can have failure of bone resorption leading to failure of eruption
Postemergent eruption
Once tooth emerges, erupts rapidly till it approaches occlusal level

- Mostly occurs between 8pm & 1am possibly related to circadian rhythm

- Following this stage is juvenile occlusal equilibration where teeth in function erupt at a rate that parallels vertical growth of ramus
Measurement of adequate spacing
Spaced arch - Baume type I
Non spaced arch - Baume Type II
Leeway space of Nance
Sum of CDE is greater than space for 345.

Averages 1.5mm/side in maxilla & 2.5mm/side in mandible
Early mesial shift
Close primate and interdental spaces before E is lost

Eruptive force of first permanent molars causes mesial migration of mandibular primary molar into mandibular primate space. Changes terminal plane into a mesial step
Late mesial shift
When mandibular permanent molar moves mesially into leeway space upon loss of mandibular second molar

- If permanent molars are edge to edge, late mesial shift allows mand molar to move into Class I after loss of E

- However, arch length is reduced
Incisor liability
When centrals erupt, they take up essentially all of that space
- Just enough space in maxilla
- Mandible has 1.6mm less space than needed
- Transitory period of mand incisor crowding at age 8-9
Arch length
Distance between line tangent to labial surface of central incisors and line connecting dorsal pts on distals of 2nd primary molar or 2nd premolar

- Decreases, increases, decreases again
Arch width
Distances between tips of canine, lingual cusp of premolars, & ML cusps of primary and permanent first molars

Increases throughout with a 3-5mm net increase
Arch circumference
Length of curved line passing over buccal cusps or incisal adge from distal surface of 2nd primary molar of 2nd premolar

Slight increase throughout
Overbite
Distance which maxillary incisal edge closes vertically past mandibular incisal edge during occlusion

Ideal - 10-15%
Mixed Dentition space analysis
Moyer's prediction chart or Tanaka & Johnson method

Measure space available and subtract total space required
- Negative is crowding, positive is space